| pubmed-article:21170267 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21170267 | lifeskim:mentions | umls-concept:C0376358 | lld:lifeskim |
| pubmed-article:21170267 | lifeskim:mentions | umls-concept:C0599295 | lld:lifeskim |
| pubmed-article:21170267 | lifeskim:mentions | umls-concept:C0034786 | lld:lifeskim |
| pubmed-article:21170267 | lifeskim:mentions | umls-concept:C1420702 | lld:lifeskim |
| pubmed-article:21170267 | lifeskim:mentions | umls-concept:C0180683 | lld:lifeskim |
| pubmed-article:21170267 | lifeskim:mentions | umls-concept:C1551083 | lld:lifeskim |
| pubmed-article:21170267 | lifeskim:mentions | umls-concept:C1879989 | lld:lifeskim |
| pubmed-article:21170267 | lifeskim:mentions | umls-concept:C1998811 | lld:lifeskim |
| pubmed-article:21170267 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:21170267 | pubmed:dateCreated | 2010-12-20 | lld:pubmed |
| pubmed-article:21170267 | pubmed:abstractText | To elucidate the role of ETS gene fusions in castration-resistant prostate cancer (CRPC), we characterized the transcriptome of 54 CRPC tumor samples from men with locally advanced or metastatic disease. Trefoil factor 3 (TFF3) emerged as the most highly differentially regulated gene with respect to ERG rearrangement status and resistance to hormone ablation therapy. Conventional chromatin immunoprecipitation (ChIP)-polymerase chain reaction and ChIP followed by DNA sequencing (ChIP-seq) revealed direct binding of ERG to ETS binding sites in the TFF3 promoter in ERG-rearranged prostate cancer cell lines. These results were confirmed in ERG-rearranged hormone-naive prostate cancer (HNPC) and CRPC tissue samples. Functional studies demonstrated that ERG has an inhibitory effect on TFF3 expression in hormone-naive cancer but not in the castration-resistant state. In addition, we provide evidence suggesting an effect of androgen receptor signaling on ERG-regulated TFF3 expression. Furthermore, TFF3 overexpression enhances ERG-mediated cell invasion in CRPC prostate cancer cells. Taken together, our findings reveal a novel mechanism for enhanced tumor cell aggressiveness resulting from ERG rearrangement in the castration-resistant setting through TFF3 gene expression. | lld:pubmed |
| pubmed-article:21170267 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:21170267 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21170267 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21170267 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21170267 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:21170267 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21170267 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21170267 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:21170267 | pubmed:issn | 1476-5586 | lld:pubmed |
| pubmed-article:21170267 | pubmed:author | pubmed-author:ChinnaiyanAru... | lld:pubmed |
| pubmed-article:21170267 | pubmed:author | pubmed-author:RubinMark AMA | lld:pubmed |
| pubmed-article:21170267 | pubmed:author | pubmed-author:RickmanDavid... | lld:pubmed |
| pubmed-article:21170267 | pubmed:author | pubmed-author:BismarTarek... | lld:pubmed |
| pubmed-article:21170267 | pubmed:author | pubmed-author:YuJindanJ | lld:pubmed |
| pubmed-article:21170267 | pubmed:author | pubmed-author:DemichelisFra... | lld:pubmed |
| pubmed-article:21170267 | pubmed:author | pubmed-author:PernerSvenS | lld:pubmed |
| pubmed-article:21170267 | pubmed:author | pubmed-author:SircarKanishk... | lld:pubmed |
| pubmed-article:21170267 | pubmed:author | pubmed-author:MertzKirsten... | lld:pubmed |
| pubmed-article:21170267 | pubmed:author | pubmed-author:ChenYing-BeiY... | lld:pubmed |
| pubmed-article:21170267 | pubmed:author | pubmed-author:SetlurSunita... | lld:pubmed |
| pubmed-article:21170267 | pubmed:author | pubmed-author:BanerjeeSampr... | lld:pubmed |
| pubmed-article:21170267 | pubmed:author | pubmed-author:PanYihangY | lld:pubmed |
| pubmed-article:21170267 | pubmed:author | pubmed-author:LafargueChris... | lld:pubmed |
| pubmed-article:21170267 | pubmed:author | pubmed-author:VuongTerryT | lld:pubmed |
| pubmed-article:21170267 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21170267 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:21170267 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21170267 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21170267 | pubmed:pagination | 1031-40 | lld:pubmed |
| pubmed-article:21170267 | pubmed:dateRevised | 2011-8-1 | lld:pubmed |
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| pubmed-article:21170267 | pubmed:meshHeading | pubmed-meshheading:21170267... | lld:pubmed |
| pubmed-article:21170267 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:21170267 | pubmed:articleTitle | ERG cooperates with androgen receptor in regulating trefoil factor 3 in prostate cancer disease progression. | lld:pubmed |
| pubmed-article:21170267 | pubmed:affiliation | Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10065, USA. | lld:pubmed |
| pubmed-article:21170267 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21170267 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:21170267 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:21170267 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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