| pubmed-article:2116988 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2116988 | lifeskim:mentions | umls-concept:C0085455 | lld:lifeskim |
| pubmed-article:2116988 | lifeskim:mentions | umls-concept:C0007608 | lld:lifeskim |
| pubmed-article:2116988 | lifeskim:mentions | umls-concept:C1521797 | lld:lifeskim |
| pubmed-article:2116988 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:2116988 | lifeskim:mentions | umls-concept:C2756052 | lld:lifeskim |
| pubmed-article:2116988 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:2116988 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:2116988 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:2116988 | lifeskim:mentions | umls-concept:C1707511 | lld:lifeskim |
| pubmed-article:2116988 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:2116988 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:2116988 | pubmed:dateCreated | 1990-9-20 | lld:pubmed |
| pubmed-article:2116988 | pubmed:abstractText | There are striking similarities between the developmental phenotypes of two different mutant classes of Myxococcus xanthus. The first class, mglA mutants, are nonmotile under all conditions tested. The second class, csgA mutants, are motile but belong to a class of signal-defective developmental mutants that cannot develop alone but will develop when mixed with intact wild-type cells. Nevertheless, both csgA and mglA mutants fail to aggregate properly or to sporulate when induced to form fruiting bodies. An mglA mutation and a csgA mutation affect expression of a panel of lacZ fusions to developmental genes in the same way, indicating that nonmotile cells and csgA cells arrest development at a similar stage. One explanation for the similarity of developmental phenotypes between these mutants is that motility is required for the csgA-mediated cell interaction. In support of this hypothesis, we report that C-factor, a protein purified from nascent wild-type fruiting bodies based on its ability to rescue csgA mutant fruiting body development, also rescues sporulation and expression of beta-galactosidase from developmentally controlled lacZ fusions in mglA strains, apparently without restoring their motility. Wild-type levels of active C-factor can be purified from mglA cells, yet intact mglA cells do not rescue csgA cells upon cell-cell mixing. Intact wild-type cells are unable to restore the sporulation and beta-galactosidase expression of mglA mutants. These results support the hypothesis that donor and responder cell motility is required for C-factor transmission between cells during development.(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
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| pubmed-article:2116988 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2116988 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2116988 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2116988 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2116988 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2116988 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2116988 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:2116988 | pubmed:issn | 0890-9369 | lld:pubmed |
| pubmed-article:2116988 | pubmed:author | pubmed-author:KaiserDD | lld:pubmed |
| pubmed-article:2116988 | pubmed:author | pubmed-author:KimS KSK | lld:pubmed |
| pubmed-article:2116988 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2116988 | pubmed:volume | 4 | lld:pubmed |
| pubmed-article:2116988 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2116988 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2116988 | pubmed:pagination | 896-904 | lld:pubmed |
| pubmed-article:2116988 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:2116988 | pubmed:meshHeading | pubmed-meshheading:2116988-... | lld:pubmed |
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| pubmed-article:2116988 | pubmed:meshHeading | pubmed-meshheading:2116988-... | lld:pubmed |
| pubmed-article:2116988 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2116988 | pubmed:articleTitle | Cell motility is required for the transmission of C-factor, an intercellular signal that coordinates fruiting body morphogenesis of Myxococcus xanthus. | lld:pubmed |
| pubmed-article:2116988 | pubmed:affiliation | Department of Biochemistry, School of Medicine, Stanford University, California 94305. | lld:pubmed |
| pubmed-article:2116988 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2116988 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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