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pubmed-article:21162142pubmed:abstractTextAccurate R2* measurements are critical for many abdominal imaging applications. Conventionally, R2* maps are derived via the monoexponential fitting of signal decay within a series of gradient-echo (GRE) images reconstructed from multichannel datasets combined using a root sum-of-squares (RSS) approach. However, the noise bias at low-SNR TEs from RSS-reconstructed data often causes the underestimation of R2* values. In phantom, ex vivo animal model and normal volunteer studies, we investigated the accuracy of low-SNR R2* measurement when combining truncation and coil combination methods. The accuracy for R2* estimations was shown to be affected by the intrinsic R2* value, SNR level and the chosen reconstruction method. The R2* estimation error was found to decrease with increasing SNR level, decreasing R2* value and the use of the optimal B1-weighted combined (OBC) image reconstruction method. Data truncation based on rigorous voxel-wise SNR estimates can reduce R2* measurement error in the setting of low SNR with fast signal decay. When optimal SNR truncation thresholds are unknown, the OBC method can provide optimal R2* measurements given the minimal truncation requirements.lld:pubmed
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pubmed-article:21162142pubmed:statusMEDLINElld:pubmed
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pubmed-article:21162142pubmed:issn1099-1492lld:pubmed
pubmed-article:21162142pubmed:authorpubmed-author:LarsonAndrew...lld:pubmed
pubmed-article:21162142pubmed:authorpubmed-author:YinXiaomingXlld:pubmed
pubmed-article:21162142pubmed:authorpubmed-author:KatsaggelosAg...lld:pubmed
pubmed-article:21162142pubmed:authorpubmed-author:ShahSaurabhSlld:pubmed
pubmed-article:21162142pubmed:copyrightInfoCopyright © 2010 John Wiley & Sons, Ltd.lld:pubmed
pubmed-article:21162142pubmed:issnTypeElectroniclld:pubmed
pubmed-article:21162142pubmed:volume23lld:pubmed
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pubmed-article:21162142pubmed:pagination1127-36lld:pubmed
pubmed-article:21162142pubmed:dateRevised2011-9-26lld:pubmed
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pubmed-article:21162142pubmed:year2010lld:pubmed
pubmed-article:21162142pubmed:articleTitleImproved R2* measurement accuracy with absolute SNR truncation and optimal coil combination.lld:pubmed
pubmed-article:21162142pubmed:affiliationXiaoming Yin, Andrew C. Larson Department of Radiology, Northwestern University, Chicago, IL, USA.lld:pubmed
pubmed-article:21162142pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:21162142pubmed:publicationTypeResearch Support, N.I.H., Extramurallld:pubmed