| pubmed-article:21156808 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21156808 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:21156808 | lifeskim:mentions | umls-concept:C0057555 | lld:lifeskim |
| pubmed-article:21156808 | lifeskim:mentions | umls-concept:C0001476 | lld:lifeskim |
| pubmed-article:21156808 | lifeskim:mentions | umls-concept:C0033634 | lld:lifeskim |
| pubmed-article:21156808 | lifeskim:mentions | umls-concept:C1412638 | lld:lifeskim |
| pubmed-article:21156808 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:21156808 | lifeskim:mentions | umls-concept:C2003941 | lld:lifeskim |
| pubmed-article:21156808 | lifeskim:mentions | umls-concept:C0808080 | lld:lifeskim |
| pubmed-article:21156808 | lifeskim:mentions | umls-concept:C0001516 | lld:lifeskim |
| pubmed-article:21156808 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:21156808 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:21156808 | lifeskim:mentions | umls-concept:C1705922 | lld:lifeskim |
| pubmed-article:21156808 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:21156808 | pubmed:dateCreated | 2011-3-1 | lld:pubmed |
| pubmed-article:21156808 | pubmed:abstractText | Darier's disease (DD) is an inherited autosomal-dominant skin disorder characterized histologically by loss of adhesion between keratinocytes. DD is typically caused by mutations in sarcoendoplasmic reticulum Ca(2+)-ATPase isoform 2 (SERCA2), a major regulator of intracellular Ca(2+) homeostasis in the skin. However, a defined role for SERCA2 in regulating intercellular adhesion remains poorly understood. We found that diminution of SERCA2 function by pharmacological inhibition or siRNA silencing in multiple human epidermal-derived cell lines was sufficient to disrupt desmosome assembly and weaken intercellular adhesive strength. Specifically, SERCA2-deficient cells exhibited up to a 60% reduction in border translocation of desmoplakin (DP), the desmosomal cytolinker protein necessary for intermediate filament (IF) anchorage to sites of robust cell-cell adhesion. In addition, loss of SERCA2 impaired the membrane translocation of protein kinase C ? (PKC?), a known regulator of DP-IF association and desmosome assembly, to the plasma membrane by up to 70%. Exogenous activation of PKC? in SERCA2-deficient cells was sufficient to rescue the defective DP localization, desmosome assembly, and intercellular adhesive strength to levels comparable to controls. Our findings indicate that SERCA2-deficiency is sufficient to impede desmosome assembly and weaken intercellular adhesive strength via a PKC?-dependent mechanism, implicating SERCA2 as a novel regulator of PKC? signaling. | lld:pubmed |
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| pubmed-article:21156808 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21156808 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21156808 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:21156808 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21156808 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:21156808 | pubmed:issn | 1530-6860 | lld:pubmed |
| pubmed-article:21156808 | pubmed:author | pubmed-author:GreenKathleen... | lld:pubmed |
| pubmed-article:21156808 | pubmed:author | pubmed-author:DenningMitche... | lld:pubmed |
| pubmed-article:21156808 | pubmed:author | pubmed-author:PrakriyaMural... | lld:pubmed |
| pubmed-article:21156808 | pubmed:author | pubmed-author:AmargoEvangel... | lld:pubmed |
| pubmed-article:21156808 | pubmed:author | pubmed-author:SimpsonCory... | lld:pubmed |
| pubmed-article:21156808 | pubmed:author | pubmed-author:HobbsRyan PRP | lld:pubmed |
| pubmed-article:21156808 | pubmed:author | pubmed-author:SomasundaramA... | lld:pubmed |
| pubmed-article:21156808 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21156808 | pubmed:volume | 25 | lld:pubmed |
| pubmed-article:21156808 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21156808 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21156808 | pubmed:pagination | 990-1001 | lld:pubmed |
| pubmed-article:21156808 | pubmed:dateRevised | 2011-5-11 | lld:pubmed |
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| pubmed-article:21156808 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21156808 | pubmed:articleTitle | The calcium ATPase SERCA2 regulates desmoplakin dynamics and intercellular adhesive strength through modulation of PKCα signaling. | lld:pubmed |
| pubmed-article:21156808 | pubmed:affiliation | Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA. | lld:pubmed |
| pubmed-article:21156808 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21156808 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:21156808 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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