| pubmed-article:21154198 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21154198 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:21154198 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:21154198 | lifeskim:mentions | umls-concept:C0964285 | lld:lifeskim |
| pubmed-article:21154198 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:21154198 | pubmed:dateCreated | 2011-5-23 | lld:pubmed |
| pubmed-article:21154198 | pubmed:abstractText | Mulberroside A is a major stilbene glycoside of MORUS ALBA L. (Moraceae), which is effectively used for the treatment of hyperuricemia and gout in traditional Chinese medicine. We examined whether mulberroside A had effects on renal urate underexcretion and dysfunction in oxonate-induced hyperuricemic mice and investigated the potential uricosuric and nephroprotective mechanisms involved. Mulberroside A at 10, 20, and 40 mg/kg decreased serum uric acid levels and increased urinary urate excretion and fractional excretion of uric acid in hyperuricemic mice. Simultaneously, it reduced serum levels of creatinine and urea nitrogen (10-40 mg/kg), urinary N-acetyl- ?-D-glucosaminidase activity (10-40 mg/kg), ??-microglobulin (10-40 mg/kg) and albumin (20-40 mg/kg), and increased creatinine clearance (10-40 mg/kg) in hyperuricemic mice. Furthermore, mulberroside A downregulated mRNA and protein levels of renal glucose transporter 9 (mGLUT9) and urate transporter 1 (mURAT1), and upregulated mRNA and protein levels of renal organic anion transporter 1 (mOAT1) and organic cation and carnitine transporters (mOCT1, mOCT2, mOCTN1, and mOCTN2) in hyperuricemic mice. This is the first study demonstrating that mulberroside A exhibits uricosuric and nephroprotective effects mediated in part by cooperative attenuation of the expression alterations of renal organic ion transporters in hyperuricemic mice. These data suggest that mulberroside A may be a new drug candidate for the treatment of hyperuricemia with renal dysfunction. | lld:pubmed |
| pubmed-article:21154198 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21154198 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21154198 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21154198 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21154198 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21154198 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21154198 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21154198 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21154198 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21154198 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21154198 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21154198 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21154198 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21154198 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21154198 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21154198 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21154198 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21154198 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21154198 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21154198 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21154198 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21154198 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21154198 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21154198 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21154198 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21154198 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21154198 | pubmed:month | May | lld:pubmed |
| pubmed-article:21154198 | pubmed:issn | 1439-0221 | lld:pubmed |
| pubmed-article:21154198 | pubmed:author | pubmed-author:ZhangXianX | lld:pubmed |
| pubmed-article:21154198 | pubmed:author | pubmed-author:WangXingX | lld:pubmed |
| pubmed-article:21154198 | pubmed:author | pubmed-author:YeJian-FengJF | lld:pubmed |
| pubmed-article:21154198 | pubmed:author | pubmed-author:KongLing-Dong... | lld:pubmed |
| pubmed-article:21154198 | pubmed:author | pubmed-author:WangYeminY | lld:pubmed |
| pubmed-article:21154198 | pubmed:author | pubmed-author:WangCai-PingC... | lld:pubmed |
| pubmed-article:21154198 | pubmed:author | pubmed-author:HuLin-ShuiLS | lld:pubmed |
| pubmed-article:21154198 | pubmed:copyrightInfo | © Georg Thieme Verlag KG Stuttgart · New York. | lld:pubmed |
| pubmed-article:21154198 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21154198 | pubmed:volume | 77 | lld:pubmed |
| pubmed-article:21154198 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21154198 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21154198 | pubmed:pagination | 786-94 | lld:pubmed |
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| pubmed-article:21154198 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21154198 | pubmed:articleTitle | Mulberroside a possesses potent uricosuric and nephroprotective effects in hyperuricemic mice. | lld:pubmed |
| pubmed-article:21154198 | pubmed:affiliation | State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, P. R. China. | lld:pubmed |
| pubmed-article:21154198 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21154198 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
