| pubmed-article:21151174 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21151174 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:21151174 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:21151174 | lifeskim:mentions | umls-concept:C0032548 | lld:lifeskim |
| pubmed-article:21151174 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:21151174 | lifeskim:mentions | umls-concept:C1257756 | lld:lifeskim |
| pubmed-article:21151174 | lifeskim:mentions | umls-concept:C1427960 | lld:lifeskim |
| pubmed-article:21151174 | pubmed:issue | 15 | lld:pubmed |
| pubmed-article:21151174 | pubmed:dateCreated | 2011-4-14 | lld:pubmed |
| pubmed-article:21151174 | pubmed:abstractText | Human polynucleotide phosphorylase (hPNPase(old-35)) is an evolutionary conserved RNA-processing enzyme with expanding roles in regulating cellular physiology. hPNPase(old-35) was cloned using an innovative 'overlapping pathway screening' strategy designed to identify genes coordinately regulated during the processes of cellular differentiation and senescence. Although hPNPase(old-35) structurally and biochemically resembles PNPase of other species, overexpression and inhibition studies reveal that hPNPase(old-35) has evolved to serve more specialized and diversified functions in humans. Targeting specific mRNA or non-coding small microRNA, hPNPase(old-35) modulates gene expression that in turn has a pivotal role in regulating normal physiological and pathological processes. In these contexts, targeted overexpression of hPNPase(old-35) represents a novel strategy to selectively downregulate RNA expression and consequently intervene in a variety of pathophysiological conditions. | lld:pubmed |
| pubmed-article:21151174 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21151174 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21151174 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21151174 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21151174 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21151174 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21151174 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21151174 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21151174 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21151174 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21151174 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21151174 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:21151174 | pubmed:issn | 1476-5594 | lld:pubmed |
| pubmed-article:21151174 | pubmed:author | pubmed-author:DasS KSK | lld:pubmed |
| pubmed-article:21151174 | pubmed:author | pubmed-author:SmithC SCS3rd | lld:pubmed |
| pubmed-article:21151174 | pubmed:author | pubmed-author:SarkarDD | lld:pubmed |
| pubmed-article:21151174 | pubmed:author | pubmed-author:FisherP BPB | lld:pubmed |
| pubmed-article:21151174 | pubmed:author | pubmed-author:DashRR | lld:pubmed |
| pubmed-article:21151174 | pubmed:author | pubmed-author:AzadDD | lld:pubmed |
| pubmed-article:21151174 | pubmed:author | pubmed-author:BhutiaS KSK | lld:pubmed |
| pubmed-article:21151174 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21151174 | pubmed:day | 14 | lld:pubmed |
| pubmed-article:21151174 | pubmed:volume | 30 | lld:pubmed |
| pubmed-article:21151174 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21151174 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21151174 | pubmed:pagination | 1733-43 | lld:pubmed |
| pubmed-article:21151174 | pubmed:meshHeading | pubmed-meshheading:21151174... | lld:pubmed |
| pubmed-article:21151174 | pubmed:meshHeading | pubmed-meshheading:21151174... | lld:pubmed |
| pubmed-article:21151174 | pubmed:meshHeading | pubmed-meshheading:21151174... | lld:pubmed |
| pubmed-article:21151174 | pubmed:meshHeading | pubmed-meshheading:21151174... | lld:pubmed |
| pubmed-article:21151174 | pubmed:meshHeading | pubmed-meshheading:21151174... | lld:pubmed |
| pubmed-article:21151174 | pubmed:meshHeading | pubmed-meshheading:21151174... | lld:pubmed |
| pubmed-article:21151174 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21151174 | pubmed:articleTitle | Human polynucleotide phosphorylase (hPNPase(old-35)): an evolutionary conserved gene with an expanding repertoire of RNA degradation functions. | lld:pubmed |
| pubmed-article:21151174 | pubmed:affiliation | Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298-0033, USA. | lld:pubmed |
| pubmed-article:21151174 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21151174 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:21151174 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:21151174 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:87178 | entrezgene:pubmed | pubmed-article:21151174 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21151174 | lld:entrezgene |
