| pubmed-article:21151131 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21151131 | lifeskim:mentions | umls-concept:C0012634 | lld:lifeskim |
| pubmed-article:21151131 | lifeskim:mentions | umls-concept:C0596508 | lld:lifeskim |
| pubmed-article:21151131 | lifeskim:mentions | umls-concept:C1171322 | lld:lifeskim |
| pubmed-article:21151131 | lifeskim:mentions | umls-concept:C0008546 | lld:lifeskim |
| pubmed-article:21151131 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:21151131 | lifeskim:mentions | umls-concept:C1150611 | lld:lifeskim |
| pubmed-article:21151131 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:21151131 | pubmed:dateCreated | 2010-12-21 | lld:pubmed |
| pubmed-article:21151131 | pubmed:abstractText | Activating mutations in the tyrosine kinase Janus kinase 2 (JAK2) cause myeloproliferative neoplasms, clonal blood stem cell disorders with a propensity for leukaemic transformation. Leukaemia inhibitory factor (LIF) signalling through the JAK-signal transducer and activator of transcription (STAT) pathway enables self-renewal of embryonic stem (ES) cells. Here we show that mouse ES cells carrying the human JAK2V617F mutation were able to self-renew in chemically defined conditions without cytokines or small-molecule inhibitors, independently of JAK signalling through the STAT3 or phosphatidylinositol-3-OH kinase pathways. Phosphorylation of histone H3 tyrosine 41 (H3Y41) by JAK2 was recently shown to interfere with binding of heterochromatin protein 1? (HP1?). Levels of chromatin-bound HP1? were lower in JAK2V617F ES cells but increased following inhibition of JAK2, coincident with a global reduction in histone H3Y41 phosphorylation. JAK2 inhibition reduced levels of the pluripotency regulator Nanog, with a reduction in H3Y41 phosphorylation and concomitant increase in HP1? levels at the Nanog promoter. Furthermore, Nanog was required for factor independence of JAK2V617F ES cells. Taken together, these results uncover a previously unrecognized role for direct signalling to chromatin by JAK2 as an important mediator of ES cell self-renewal. | lld:pubmed |
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| pubmed-article:21151131 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21151131 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21151131 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21151131 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:21151131 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21151131 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:21151131 | pubmed:issn | 1476-4679 | lld:pubmed |
| pubmed-article:21151131 | pubmed:author | pubmed-author:LiuPentaoP | lld:pubmed |
| pubmed-article:21151131 | pubmed:author | pubmed-author:KouzaridesTon... | lld:pubmed |
| pubmed-article:21151131 | pubmed:author | pubmed-author:LiJuanJ | lld:pubmed |
| pubmed-article:21151131 | pubmed:author | pubmed-author:GreenAnthony... | lld:pubmed |
| pubmed-article:21151131 | pubmed:author | pubmed-author:NicholsJennif... | lld:pubmed |
| pubmed-article:21151131 | pubmed:author | pubmed-author:GöttgensBerth... | lld:pubmed |
| pubmed-article:21151131 | pubmed:author | pubmed-author:BannisterAndr... | lld:pubmed |
| pubmed-article:21151131 | pubmed:author | pubmed-author:MansfieldWill... | lld:pubmed |
| pubmed-article:21151131 | pubmed:author | pubmed-author:TrotterMatthe... | lld:pubmed |
| pubmed-article:21151131 | pubmed:author | pubmed-author:DawsonMark... | lld:pubmed |
| pubmed-article:21151131 | pubmed:author | pubmed-author:SmithAileen... | lld:pubmed |
| pubmed-article:21151131 | pubmed:author | pubmed-author:GriffithsDean... | lld:pubmed |
| pubmed-article:21151131 | pubmed:author | pubmed-author:ChengYi-HanYH | lld:pubmed |
| pubmed-article:21151131 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21151131 | pubmed:volume | 13 | lld:pubmed |
| pubmed-article:21151131 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21151131 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21151131 | pubmed:pagination | 13-21 | lld:pubmed |
| pubmed-article:21151131 | pubmed:dateRevised | 2011-8-1 | lld:pubmed |
| pubmed-article:21151131 | pubmed:meshHeading | pubmed-meshheading:21151131... | lld:pubmed |
| pubmed-article:21151131 | pubmed:meshHeading | pubmed-meshheading:21151131... | lld:pubmed |
