| pubmed-article:2115000 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2115000 | lifeskim:mentions | umls-concept:C0282641 | lld:lifeskim |
| pubmed-article:2115000 | lifeskim:mentions | umls-concept:C0021036 | lld:lifeskim |
| pubmed-article:2115000 | lifeskim:mentions | umls-concept:C0544886 | lld:lifeskim |
| pubmed-article:2115000 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:2115000 | pubmed:dateCreated | 1990-8-23 | lld:pubmed |
| pubmed-article:2115000 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2115000 | pubmed:abstractText | Analysis of mice transgenic for immunoglobulin genes should allow definition of the cis-acting DNA sequences required to target somatic mutation to antibody V genes. We have looked for mutations in a chimeric kappa transgene encoding a V region specific for the hapten 2-phenyloxazolone (phOx) linked to a rat C kappa gene. Two independent lines of transgenic mice were hyperimmunized with phOx and splenic hybridomas established. In B cells that had been selected by antigen and which used mouse anti-phOx genes, the endogenous sequences were found to be mutated whereas the transgene remained unchanged. These results suggest either that (a) if the transgene is a "passenger" gene expressed at a low level, transgene mutation is a rare event, or that (b) sequences far from the kappa coding region are necessary to direct somatic mutation. | lld:pubmed |
| pubmed-article:2115000 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2115000 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2115000 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2115000 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2115000 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2115000 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2115000 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2115000 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2115000 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:2115000 | pubmed:issn | 0014-2980 | lld:pubmed |
| pubmed-article:2115000 | pubmed:author | pubmed-author:NeubergerMM | lld:pubmed |
| pubmed-article:2115000 | pubmed:author | pubmed-author:MilsteinCC | lld:pubmed |
| pubmed-article:2115000 | pubmed:author | pubmed-author:PannellRR | lld:pubmed |
| pubmed-article:2115000 | pubmed:author | pubmed-author:SuraniM AMA | lld:pubmed |
| pubmed-article:2115000 | pubmed:author | pubmed-author:SharpeM JMJ | lld:pubmed |
| pubmed-article:2115000 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2115000 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:2115000 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2115000 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2115000 | pubmed:pagination | 1379-85 | lld:pubmed |
| pubmed-article:2115000 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2115000 | pubmed:meshHeading | pubmed-meshheading:2115000-... | lld:pubmed |
| pubmed-article:2115000 | pubmed:meshHeading | pubmed-meshheading:2115000-... | lld:pubmed |
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| pubmed-article:2115000 | pubmed:meshHeading | pubmed-meshheading:2115000-... | lld:pubmed |
| pubmed-article:2115000 | pubmed:meshHeading | pubmed-meshheading:2115000-... | lld:pubmed |
| pubmed-article:2115000 | pubmed:meshHeading | pubmed-meshheading:2115000-... | lld:pubmed |
| pubmed-article:2115000 | pubmed:meshHeading | pubmed-meshheading:2115000-... | lld:pubmed |
| pubmed-article:2115000 | pubmed:meshHeading | pubmed-meshheading:2115000-... | lld:pubmed |
| pubmed-article:2115000 | pubmed:meshHeading | pubmed-meshheading:2115000-... | lld:pubmed |
| pubmed-article:2115000 | pubmed:meshHeading | pubmed-meshheading:2115000-... | lld:pubmed |
| pubmed-article:2115000 | pubmed:meshHeading | pubmed-meshheading:2115000-... | lld:pubmed |
| pubmed-article:2115000 | pubmed:meshHeading | pubmed-meshheading:2115000-... | lld:pubmed |
| pubmed-article:2115000 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2115000 | pubmed:articleTitle | Lack of somatic mutation in a kappa light chain transgene. | lld:pubmed |
| pubmed-article:2115000 | pubmed:affiliation | MRC Laboratory of Molecular Biology, Cambridge, GB. | lld:pubmed |
| pubmed-article:2115000 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2115000 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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