| pubmed-article:2113875 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2113875 | lifeskim:mentions | umls-concept:C0039005 | lld:lifeskim |
| pubmed-article:2113875 | lifeskim:mentions | umls-concept:C0036770 | lld:lifeskim |
| pubmed-article:2113875 | lifeskim:mentions | umls-concept:C0007585 | lld:lifeskim |
| pubmed-article:2113875 | lifeskim:mentions | umls-concept:C0007582 | lld:lifeskim |
| pubmed-article:2113875 | lifeskim:mentions | umls-concept:C0021665 | lld:lifeskim |
| pubmed-article:2113875 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:2113875 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:2113875 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2113875 | pubmed:dateCreated | 1990-8-8 | lld:pubmed |
| pubmed-article:2113875 | pubmed:abstractText | The production of insulin-like growth factor I (IGF-I) by pig Leydig cells and pig Sertoli cells cultured alone or together was investigated. Human chorionic gonadotropin (hCG) and basic fibroblast growth factor (FGF) stimulate in a dose-dependent manner IGF-I production by Leydig cells. At maximal concentrations the effects of both factors were almost additive. Insulin at micromolar concentrations enhanced IGF-I production and potentiated the effects of hCG and FGF. The secretion of IGF-I by Sertoli cells was stimulated by FSH and FGF. Under basal conditions, the production of IGF-I by the coculture was similar to the addition of the production by each cell cultured alone. In contrast, in the presence of hCG, FSH or FGF, the production of IGF-I by the coculture largely exceeded that expected from the monocultures. Moreover, stimulation of the coculture with both hCG and FSH resulted in a further increase in IGF-I production. These results indicate that Leydig as well as Sertoli cells secrete IGF-I and that the secretion of both cell types is stimulated by the corresponding gonadotropin. In addition, they indicate that Leydig-Sertoli interactions play a role in the control of IGF-I production, supporting the contention that this growth factor plays an important role in the paracrine and autocrine control of testicular functions. | lld:pubmed |
| pubmed-article:2113875 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2113875 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2113875 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2113875 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2113875 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2113875 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2113875 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2113875 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2113875 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2113875 | pubmed:month | May | lld:pubmed |
| pubmed-article:2113875 | pubmed:issn | 0303-7207 | lld:pubmed |
| pubmed-article:2113875 | pubmed:author | pubmed-author:SaezJ MJM | lld:pubmed |
| pubmed-article:2113875 | pubmed:author | pubmed-author:AvalletOO | lld:pubmed |
| pubmed-article:2113875 | pubmed:author | pubmed-author:ChatelainP... | lld:pubmed |
| pubmed-article:2113875 | pubmed:author | pubmed-author:NavilleDD | lld:pubmed |
| pubmed-article:2113875 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2113875 | pubmed:day | 7 | lld:pubmed |
| pubmed-article:2113875 | pubmed:volume | 70 | lld:pubmed |
| pubmed-article:2113875 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2113875 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2113875 | pubmed:pagination | 217-24 | lld:pubmed |
| pubmed-article:2113875 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2113875 | pubmed:meshHeading | pubmed-meshheading:2113875-... | lld:pubmed |
| pubmed-article:2113875 | pubmed:meshHeading | pubmed-meshheading:2113875-... | lld:pubmed |
| pubmed-article:2113875 | pubmed:meshHeading | pubmed-meshheading:2113875-... | lld:pubmed |
| pubmed-article:2113875 | pubmed:meshHeading | pubmed-meshheading:2113875-... | lld:pubmed |
| pubmed-article:2113875 | pubmed:meshHeading | pubmed-meshheading:2113875-... | lld:pubmed |
| pubmed-article:2113875 | pubmed:meshHeading | pubmed-meshheading:2113875-... | lld:pubmed |
| pubmed-article:2113875 | pubmed:meshHeading | pubmed-meshheading:2113875-... | lld:pubmed |
| pubmed-article:2113875 | pubmed:meshHeading | pubmed-meshheading:2113875-... | lld:pubmed |
| pubmed-article:2113875 | pubmed:meshHeading | pubmed-meshheading:2113875-... | lld:pubmed |
| pubmed-article:2113875 | pubmed:meshHeading | pubmed-meshheading:2113875-... | lld:pubmed |
| pubmed-article:2113875 | pubmed:meshHeading | pubmed-meshheading:2113875-... | lld:pubmed |
| pubmed-article:2113875 | pubmed:meshHeading | pubmed-meshheading:2113875-... | lld:pubmed |
| pubmed-article:2113875 | pubmed:meshHeading | pubmed-meshheading:2113875-... | lld:pubmed |
| pubmed-article:2113875 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2113875 | pubmed:articleTitle | Control of production of insulin-like growth factor I by pig Leydig and Sertoli cells cultured alone or together. Cell-cell interactions. | lld:pubmed |
| pubmed-article:2113875 | pubmed:affiliation | INSERM U 307, Hôpital Debrousse, Lyon, France. | lld:pubmed |
| pubmed-article:2113875 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2113875 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
