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| pubmed-article:21128618 | lifeskim:mentions | umls-concept:C1705422 | lld:lifeskim |
| pubmed-article:21128618 | lifeskim:mentions | umls-concept:C1709060 | lld:lifeskim |
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| pubmed-article:21128618 | lifeskim:mentions | umls-concept:C1521840 | lld:lifeskim |
| pubmed-article:21128618 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:21128618 | pubmed:dateCreated | 2011-9-15 | lld:pubmed |
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| pubmed-article:21128618 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21128618 | pubmed:abstractText | A novel series of AMPAR positive modulators is described that were identified by high throughput screening. The molecules of the series have been optimized from a high quality starting point hit to afford excellent developability, tolerability, and efficacy profiles, leading to identification of a clinical candidate. Unusually for an ion channel target, this optimization was integrated with regular generation of ligand-bound crystal structures and uncovered a novel chemotype with a unique and highly conserved mode of interaction via a trifluoromethyl group. | lld:pubmed |
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| pubmed-article:21128618 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:21128618 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:21128618 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21128618 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:21128618 | pubmed:issn | 1520-4804 | lld:pubmed |
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| pubmed-article:21128618 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21128618 | pubmed:day | 13 | lld:pubmed |
| pubmed-article:21128618 | pubmed:volume | 54 | lld:pubmed |
| pubmed-article:21128618 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21128618 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21128618 | pubmed:pagination | 78-94 | lld:pubmed |
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| pubmed-article:21128618 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21128618 | pubmed:articleTitle | Integration of lead optimization with crystallography for a membrane-bound ion channel target: discovery of a new class of AMPA receptor positive allosteric modulators. | lld:pubmed |
| pubmed-article:21128618 | pubmed:affiliation | School of Life Sciences, University of Sussex, Brighton, United Kingdom. simon.ward@sussex.ac.uk | lld:pubmed |
| pubmed-article:21128618 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21128618 | pubmed:publicationType | In Vitro | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:21128618 | lld:chembl |
