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pubmed-article:21125413pubmed:issue4lld:pubmed
pubmed-article:21125413pubmed:dateCreated2011-3-22lld:pubmed
pubmed-article:21125413pubmed:abstractTextImplantation of chondrocytes isolated from patients and expanded in number in vitro is being used to treat patients with cartilage injuries. However, chondrocytes de-differentiate during culture with several passages, and cartilage regenerated by implantation of de-differentiated chondrocytes may be suboptimal. Here, we show that a spinner-flask culture system induces formation of chondrocyte aggregates and redifferentiate de-differentiated chondrocytes. Spinner-flask cultures induced the aggregate formation of chondrocytes with passage 1 or 4. Importantly, spinner-flask cultures induced redifferentiation of the de-differentiated chondrocytes, as type I collagen expression was significantly lower and type II collagen expression was significantly higher in spinner flask-cultured chondrocytes than in monolayer-cultured chondrocytes. This system is easily scalable and could be feasible for clinical setting.lld:pubmed
pubmed-article:21125413pubmed:languageenglld:pubmed
pubmed-article:21125413pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
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pubmed-article:21125413pubmed:issn1573-6776lld:pubmed
pubmed-article:21125413pubmed:authorpubmed-author:LeeHaeshinHlld:pubmed
pubmed-article:21125413pubmed:authorpubmed-author:KimByung-SooB...lld:pubmed
pubmed-article:21125413pubmed:authorpubmed-author:ImGun-IlGIlld:pubmed
pubmed-article:21125413pubmed:authorpubmed-author:LeeTae-JinTJlld:pubmed
pubmed-article:21125413pubmed:authorpubmed-author:LeeSoo-HongSHlld:pubmed
pubmed-article:21125413pubmed:authorpubmed-author:BhangSuk HoSHlld:pubmed
pubmed-article:21125413pubmed:authorpubmed-author:YangHee...lld:pubmed
pubmed-article:21125413pubmed:authorpubmed-author:LaWan-GuenWGlld:pubmed
pubmed-article:21125413pubmed:authorpubmed-author:SeongJun...lld:pubmed
pubmed-article:21125413pubmed:issnTypeElectroniclld:pubmed
pubmed-article:21125413pubmed:volume33lld:pubmed
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pubmed-article:21125413pubmed:pagination829-36lld:pubmed
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pubmed-article:21125413pubmed:year2011lld:pubmed
pubmed-article:21125413pubmed:articleTitleSpinner-flask culture induces redifferentiation of de-differentiated chondrocytes.lld:pubmed
pubmed-article:21125413pubmed:affiliationDepartment of Bioengineering, Hanyang University, Seoul, Republic of Korea.lld:pubmed
pubmed-article:21125413pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:21125413pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed