| pubmed-article:2112350 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2112350 | lifeskim:mentions | umls-concept:C0026926 | lld:lifeskim |
| pubmed-article:2112350 | lifeskim:mentions | umls-concept:C0014964 | lld:lifeskim |
| pubmed-article:2112350 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:2112350 | lifeskim:mentions | umls-concept:C0039476 | lld:lifeskim |
| pubmed-article:2112350 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:2112350 | lifeskim:mentions | umls-concept:C0678756 | lld:lifeskim |
| pubmed-article:2112350 | lifeskim:mentions | umls-concept:C2348485 | lld:lifeskim |
| pubmed-article:2112350 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:2112350 | pubmed:dateCreated | 1990-7-9 | lld:pubmed |
| pubmed-article:2112350 | pubmed:abstractText | In a series of dynamic in vitro studies designed to assess the activity of ethambutol (EMB) against Mycobacterium tuberculosis, we made the following observations. Ethambutol showed bactericidal action with 10 micrograms/ml concentration when in constant contact with M. tuberculosis. At a lower concentration, bactericidal action was evident up to 6 days; after that time, this effect was lost owing to the development of drug-resistant mutants. The bactericidal action of ethambutol in this model was similar to that of rifampin and isoniazid. Pulsed exposure for 96 h caused a four-log reduction in cfu counts, but the growth resumed rapidly. The bactericidal action of ethambutol was maximal at 37 degrees C and less at low temperatures. Ethambutol showed little activity against cultures growing at 8 degrees C continuously that were incubated for only 1 h at 37 degrees C. Against cultures growing at 8 degrees C that were brought to 37 degrees C for 6 h, its action was similar to that of rifampin. Ethambutol combined with other drugs showed bactericidal action, although the activity was less than that of the combination isoniazid-streptomycin. | lld:pubmed |
| pubmed-article:2112350 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2112350 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2112350 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2112350 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:2112350 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2112350 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2112350 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:2112350 | pubmed:issn | 0003-0805 | lld:pubmed |
| pubmed-article:2112350 | pubmed:author | pubmed-author:GangadharamP... | lld:pubmed |
| pubmed-article:2112350 | pubmed:author | pubmed-author:IsemanM DMD | lld:pubmed |
| pubmed-article:2112350 | pubmed:author | pubmed-author:PrattP FPF | lld:pubmed |
| pubmed-article:2112350 | pubmed:author | pubmed-author:PerumalV KVK | lld:pubmed |
| pubmed-article:2112350 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2112350 | pubmed:volume | 141 | lld:pubmed |
| pubmed-article:2112350 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2112350 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2112350 | pubmed:pagination | 1478-82 | lld:pubmed |
| pubmed-article:2112350 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:2112350 | pubmed:meshHeading | pubmed-meshheading:2112350-... | lld:pubmed |
| pubmed-article:2112350 | pubmed:meshHeading | pubmed-meshheading:2112350-... | lld:pubmed |
| pubmed-article:2112350 | pubmed:meshHeading | pubmed-meshheading:2112350-... | lld:pubmed |
| pubmed-article:2112350 | pubmed:meshHeading | pubmed-meshheading:2112350-... | lld:pubmed |
| pubmed-article:2112350 | pubmed:meshHeading | pubmed-meshheading:2112350-... | lld:pubmed |
| pubmed-article:2112350 | pubmed:meshHeading | pubmed-meshheading:2112350-... | lld:pubmed |
| pubmed-article:2112350 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2112350 | pubmed:articleTitle | The effects of exposure time, drug concentration, and temperature on the activity of ethambutol versus Mycobacterium tuberculosis. | lld:pubmed |
| pubmed-article:2112350 | pubmed:affiliation | National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206. | lld:pubmed |
| pubmed-article:2112350 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2112350 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:2112350 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2112350 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2112350 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2112350 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2112350 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2112350 | lld:pubmed |
