| pubmed-article:21123384 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21123384 | lifeskim:mentions | umls-concept:C1184482 | lld:lifeskim |
| pubmed-article:21123384 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:21123384 | lifeskim:mentions | umls-concept:C1424917 | lld:lifeskim |
| pubmed-article:21123384 | lifeskim:mentions | umls-concept:C0443288 | lld:lifeskim |
| pubmed-article:21123384 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:21123384 | lifeskim:mentions | umls-concept:C1552961 | lld:lifeskim |
| pubmed-article:21123384 | lifeskim:mentions | umls-concept:C0205224 | lld:lifeskim |
| pubmed-article:21123384 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:21123384 | pubmed:dateCreated | 2011-1-21 | lld:pubmed |
| pubmed-article:21123384 | pubmed:abstractText | Members of the human APOBEC3 family of editing enzymes can inhibit various mobile genetic elements. APOBEC3A (A3A) can block the retrotransposon LINE-1 and the parvovirus adeno-associated virus type 2 (AAV-2) but does not inhibit retroviruses. In contrast, APOBEC3G (A3G) can block retroviruses but has only limited effects on AAV-2 or LINE-1. What dictates this differential target specificity remains largely undefined. Here, we modeled the structure of A3A based on its homology with the C-terminal domain of A3G and further compared the sequence of human A3A to those of 11 nonhuman primate orthologues. We then used these data to perform a mutational analysis of A3A, examining its ability to restrict LINE-1, AAV-2, and foreign plasmid DNA and to edit a single-stranded DNA substrate. The results revealed an essential functional role for the predicted single-stranded DNA-docking groove located around the A3A catalytic site. Within this region, amino acid differences between A3A and A3G are predicted to affect the shape of the polynucleotide-binding groove. Correspondingly, transferring some of these A3A residues to A3G endows the latter protein with the ability to block LINE-1 and AAV-2. These results suggest that the target specificity of APOBEC3 family members is partly defined by structural features influencing their interaction with polynucleotide substrates. | lld:pubmed |
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| pubmed-article:21123384 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21123384 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21123384 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21123384 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:21123384 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21123384 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21123384 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:21123384 | pubmed:issn | 1098-5514 | lld:pubmed |
| pubmed-article:21123384 | pubmed:author | pubmed-author:TelentiAmalio... | lld:pubmed |
| pubmed-article:21123384 | pubmed:author | pubmed-author:TronoDidierD | lld:pubmed |
| pubmed-article:21123384 | pubmed:author | pubmed-author:WeitzmanMatth... | lld:pubmed |
| pubmed-article:21123384 | pubmed:author | pubmed-author:RöhrigUte FUF | lld:pubmed |
| pubmed-article:21123384 | pubmed:author | pubmed-author:MichielinOliv... | lld:pubmed |
| pubmed-article:21123384 | pubmed:author | pubmed-author:ZoeteVincentV | lld:pubmed |
| pubmed-article:21123384 | pubmed:author | pubmed-author:TurelliPrisci... | lld:pubmed |
| pubmed-article:21123384 | pubmed:author | pubmed-author:NarvaizaIñigo... | lld:pubmed |
| pubmed-article:21123384 | pubmed:author | pubmed-author:BulliardYanni... | lld:pubmed |
| pubmed-article:21123384 | pubmed:author | pubmed-author:PeddiShyamS | lld:pubmed |
| pubmed-article:21123384 | pubmed:author | pubmed-author:OrtizMillánM | lld:pubmed |
| pubmed-article:21123384 | pubmed:author | pubmed-author:BerteroAlessa... | lld:pubmed |
| pubmed-article:21123384 | pubmed:author | pubmed-author:Castro-DíazNa... | lld:pubmed |
| pubmed-article:21123384 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21123384 | pubmed:volume | 85 | lld:pubmed |
| pubmed-article:21123384 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21123384 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21123384 | pubmed:pagination | 1765-76 | lld:pubmed |
| pubmed-article:21123384 | pubmed:dateRevised | 2011-11-10 | lld:pubmed |
| pubmed-article:21123384 | pubmed:meshHeading | pubmed-meshheading:21123384... | lld:pubmed |
