| pubmed-article:21119622 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21119622 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:21119622 | lifeskim:mentions | umls-concept:C0242767 | lld:lifeskim |
| pubmed-article:21119622 | lifeskim:mentions | umls-concept:C1186763 | lld:lifeskim |
| pubmed-article:21119622 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:21119622 | lifeskim:mentions | umls-concept:C0229601 | lld:lifeskim |
| pubmed-article:21119622 | lifeskim:mentions | umls-concept:C2717959 | lld:lifeskim |
| pubmed-article:21119622 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:21119622 | lifeskim:mentions | umls-concept:C0332325 | lld:lifeskim |
| pubmed-article:21119622 | lifeskim:mentions | umls-concept:C0079411 | lld:lifeskim |
| pubmed-article:21119622 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:21119622 | pubmed:dateCreated | 2011-3-1 | lld:pubmed |
| pubmed-article:21119622 | pubmed:abstractText | Induced pluripotent stem cells (iPSCs) have radically advanced the field of regenerative medicine by making possible the production of patient-specific pluripotent stem cells from adult individuals. By developing iPSCs to treat HIV, there is the potential for generating a continuous supply of therapeutic cells for transplantation into HIV-infected patients. In this study, we have used human hematopoietic stem cells (HSCs) to generate anti-HIV gene expressing iPSCs for HIV gene therapy. HSCs were dedifferentiated into continuously growing iPSC lines with four reprogramming factors and a combination anti-HIV lentiviral vector containing a CCR5 short hairpin RNA (shRNA) and a human/rhesus chimeric TRIM5? gene. Upon directed differentiation of the anti-HIV iPSCs toward the hematopoietic lineage, a robust quantity of colony-forming CD133(+) HSCs were obtained. These cells were further differentiated into functional end-stage macrophages which displayed a normal phenotypic profile. Upon viral challenge, the anti-HIV iPSC-derived macrophages exhibited strong protection from HIV-1 infection. Here, we demonstrate the ability of iPSCs to develop into HIV-1 resistant immune cells and highlight the potential use of iPSCs for HIV gene and cellular therapies. | lld:pubmed |
| pubmed-article:21119622 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21119622 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21119622 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21119622 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21119622 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21119622 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21119622 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21119622 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21119622 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21119622 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21119622 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21119622 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21119622 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21119622 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21119622 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:21119622 | pubmed:issn | 1525-0024 | lld:pubmed |
| pubmed-article:21119622 | pubmed:author | pubmed-author:DylanTT | lld:pubmed |
| pubmed-article:21119622 | pubmed:author | pubmed-author:NoltaJan AJA | lld:pubmed |
| pubmed-article:21119622 | pubmed:author | pubmed-author:BauerGerhardG | lld:pubmed |
| pubmed-article:21119622 | pubmed:author | pubmed-author:AndersonJosep... | lld:pubmed |
| pubmed-article:21119622 | pubmed:author | pubmed-author:JungYunjoonY | lld:pubmed |
| pubmed-article:21119622 | pubmed:author | pubmed-author:LindseyMattM | lld:pubmed |
| pubmed-article:21119622 | pubmed:author | pubmed-author:McGeeJeannine... | lld:pubmed |
| pubmed-article:21119622 | pubmed:author | pubmed-author:KalomoirisSte... | lld:pubmed |
| pubmed-article:21119622 | pubmed:author | pubmed-author:KambalAmalA | lld:pubmed |
| pubmed-article:21119622 | pubmed:author | pubmed-author:MitchellGaela... | lld:pubmed |
| pubmed-article:21119622 | pubmed:author | pubmed-author:CaryWhitneyW | lld:pubmed |
| pubmed-article:21119622 | pubmed:author | pubmed-author:GruenlohWilli... | lld:pubmed |
| pubmed-article:21119622 | pubmed:author | pubmed-author:NaceyCatherin... | lld:pubmed |
| pubmed-article:21119622 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21119622 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:21119622 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21119622 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21119622 | pubmed:pagination | 584-93 | lld:pubmed |
| pubmed-article:21119622 | pubmed:meshHeading | pubmed-meshheading:21119622... | lld:pubmed |
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| pubmed-article:21119622 | pubmed:meshHeading | pubmed-meshheading:21119622... | lld:pubmed |
| pubmed-article:21119622 | pubmed:meshHeading | pubmed-meshheading:21119622... | lld:pubmed |
| pubmed-article:21119622 | pubmed:meshHeading | pubmed-meshheading:21119622... | lld:pubmed |
| pubmed-article:21119622 | pubmed:meshHeading | pubmed-meshheading:21119622... | lld:pubmed |
| pubmed-article:21119622 | pubmed:meshHeading | pubmed-meshheading:21119622... | lld:pubmed |
| pubmed-article:21119622 | pubmed:meshHeading | pubmed-meshheading:21119622... | lld:pubmed |
| pubmed-article:21119622 | pubmed:meshHeading | pubmed-meshheading:21119622... | lld:pubmed |
| pubmed-article:21119622 | pubmed:meshHeading | pubmed-meshheading:21119622... | lld:pubmed |
| pubmed-article:21119622 | pubmed:meshHeading | pubmed-meshheading:21119622... | lld:pubmed |
| pubmed-article:21119622 | pubmed:meshHeading | pubmed-meshheading:21119622... | lld:pubmed |
| pubmed-article:21119622 | pubmed:meshHeading | pubmed-meshheading:21119622... | lld:pubmed |
| pubmed-article:21119622 | pubmed:meshHeading | pubmed-meshheading:21119622... | lld:pubmed |
| pubmed-article:21119622 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21119622 | pubmed:articleTitle | Generation of HIV-1 resistant and functional macrophages from hematopoietic stem cell-derived induced pluripotent stem cells. | lld:pubmed |
| pubmed-article:21119622 | pubmed:affiliation | Stem Cell Program, Department of Internal Medicine, University of California, Davis, Sacramento, California 95817, USA. | lld:pubmed |
| pubmed-article:21119622 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21119622 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:21119622 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
