| pubmed-article:21118986 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21118986 | lifeskim:mentions | umls-concept:C0018956 | lld:lifeskim |
| pubmed-article:21118986 | lifeskim:mentions | umls-concept:C1515021 | lld:lifeskim |
| pubmed-article:21118986 | pubmed:issue | 50 | lld:pubmed |
| pubmed-article:21118986 | pubmed:dateCreated | 2011-3-22 | lld:pubmed |
| pubmed-article:21118986 | pubmed:abstractText | MicroRNAs profoundly impact hematopoietic cells by regulating progenitor cell-fate decisions, as well as mature immune effector function. However to date, microRNAs that regulate hematopoietic stem cell (HSC) function have been less well characterized. Here we show that microRNA-125b (miR-125b) is highly expressed in HSCs and its expression decreases in committed progenitors. Overexpression of miR-125b in mouse HSC enhances their function, demonstrated through serial transplantation of highly purified HSC, and enriches for the previously described Slamf1(lo)CD34(-) lymphoid-balanced and the Slamf1(neg)CD34(-) lymphoid-biased cell subsets within the multipotent HSC (CD34-KLS) fraction. Mature peripheral blood cells derived from the miR-125b-overexpressing HSC are skewed toward the lymphoid lineage. Consistent with this observation, miR-125b overexpression significantly increases the number of early B-progenitor cells within the spleen and induces the expansion and enrichment of the lymphoid-balanced and lymphoid-biased HSC subset via an antiapoptotic mechanism, reducing the mRNA expression levels of two proapoptotic targets, Bmf and KLF13. The antiapoptotic effect of miR-125b is more pronounced in the lymphoid-biased HSC subset because of their intrinsic higher baseline levels of apoptosis. These effects of miR-125b are associated with the development of lymphoproliferative disease, marked by expansion of CD8(+) T lymphocytes. Taken together, these data reveal that miR-125b regulates HSC survival and can promote lymphoid-fate decisions at the level of the HSC by preferentially expanding lymphoid-balanced and lymphoid-biased HSC. | lld:pubmed |
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| pubmed-article:21118986 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21118986 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21118986 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:21118986 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21118986 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:21118986 | pubmed:issn | 1091-6490 | lld:pubmed |
| pubmed-article:21118986 | pubmed:author | pubmed-author:WeissmanIrvin... | lld:pubmed |
| pubmed-article:21118986 | pubmed:author | pubmed-author:WangYuleiY | lld:pubmed |
| pubmed-article:21118986 | pubmed:author | pubmed-author:AdornoMaddale... | lld:pubmed |
| pubmed-article:21118986 | pubmed:author | pubmed-author:OoiA G LisaAG | lld:pubmed |
| pubmed-article:21118986 | pubmed:author | pubmed-author:SahooDebashis... | lld:pubmed |
| pubmed-article:21118986 | pubmed:author | pubmed-author:ParkChristoph... | lld:pubmed |
| pubmed-article:21118986 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21118986 | pubmed:day | 14 | lld:pubmed |
| pubmed-article:21118986 | pubmed:volume | 107 | lld:pubmed |
| pubmed-article:21118986 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21118986 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21118986 | pubmed:pagination | 21505-10 | lld:pubmed |
| pubmed-article:21118986 | pubmed:dateRevised | 2011-8-1 | lld:pubmed |
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| pubmed-article:21118986 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:21118986 | pubmed:articleTitle | MicroRNA-125b expands hematopoietic stem cells and enriches for the lymphoid-balanced and lymphoid-biased subsets. | lld:pubmed |
| pubmed-article:21118986 | pubmed:affiliation | Department of Pathology, Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. | lld:pubmed |
| pubmed-article:21118986 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21118986 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:21118986 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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