Linked Life Data

21118936

Source:http://linkedlifedata.com/resource/pubmed/id/21118936

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pubmed-article:21118936pubmed:dateCreated2010-12-1lld:pubmed
pubmed-article:21118936pubmed:abstractTextLeishmania infantum causes visceral leishmaniasis, a severe zoonotic and systemic disease that is fatal if left untreated. Identification of the antigens involved in Leishmania-specific protective immune response is a research priority for the development of effective control measures. For this purpose, we evaluated, in 27 dogs from an enzootic zone, specific humoral and cellular immune response by delayed-type hypersensitivity (DTH) skin test both against total L. infantum antigen and the raw Trichoplusia ni insect-derived kinetoplastid membrane protein-11 (rKMPII), tryparedoxin peroxidase (rTRYP), Leishmania homologue of receptors for activated C kinase (rLACK), and 22-kDa potentially aggravating protein of Leishmania (rpapLe22) antigens from this parasite. rTRYP induced the highest number of positive DTH responses (55% of leishmanin skin test [LST]-positive dogs), showing that TRYP antigen is an important T cell immunogen, and it could be a promising vaccine candidate against this disease. When TRYP-DTH and KMPII-DTH tests were evaluated in parallel, 82% of LST-positive dogs were detected, suggesting that both antigens could be considered as components of a standardized DTH immunodiagnostic tool for dogs.lld:pubmed
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pubmed-article:21118936pubmed:year2010lld:pubmed
pubmed-article:21118936pubmed:articleTitleHumoral and in vivo cellular immunity against the raw insect-derived recombinant Leishmania infantum antigens KMPII, TRYP, LACK, and papLe22 in dogs from an endemic area.lld:pubmed
pubmed-article:21118936pubmed:affiliationUnitat de Farmacologia Veterinària and LeishLAB-Servei d'Anàlisi de Fàrmacs, Departament de Farmacologia, de Terapèutica i de Toxicologia, Universitat Autònoma de Barcelona, Barcelona, Spain. Felicitat.Todoli@uab.catlld:pubmed
pubmed-article:21118936pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:21118936pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed