| pubmed-article:2111585 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2111585 | lifeskim:mentions | umls-concept:C0005821 | lld:lifeskim |
| pubmed-article:2111585 | lifeskim:mentions | umls-concept:C0085151 | lld:lifeskim |
| pubmed-article:2111585 | lifeskim:mentions | umls-concept:C0005789 | lld:lifeskim |
| pubmed-article:2111585 | lifeskim:mentions | umls-concept:C0376315 | lld:lifeskim |
| pubmed-article:2111585 | pubmed:issue | 4959 | lld:pubmed |
| pubmed-article:2111585 | pubmed:dateCreated | 1990-6-26 | lld:pubmed |
| pubmed-article:2111585 | pubmed:abstractText | An inhibitor of coagulation factor XIa was purified from serum-free conditioned medium of HepG2 liver cells. Platelets stimulated with thrombin or calcium ionophore (A23187) secrete a protein functionally and immunologically identical to the inhibitor, implying a role for this inhibitor in hemostasis. Analysis of the amino-terminal amino acid sequence and immunologic reactivity showed the inhibitor to be a truncated form of the Alzheimer's amyloid precursor protein that contains a Kunitz-type serine protease inhibitor domain and at least a portion of the amyloid beta protein. It inhibits factor XIa and trypsin with a Ki of 450 +/- 50 pM and 20 +/- 10 pM, respectively. Heparin (1 unit/ml) did not significantly effect inhibition of trypsin, but inhibition of XIa was 15 times greater (Ki = 25 +/- 15 pM) in the presence of heparin. | lld:pubmed |
| pubmed-article:2111585 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2111585 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2111585 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2111585 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2111585 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:2111585 | pubmed:issn | 0036-8075 | lld:pubmed |
| pubmed-article:2111585 | pubmed:author | pubmed-author:SmithR PRP | lld:pubmed |
| pubmed-article:2111585 | pubmed:author | pubmed-author:BrozeG JGJJr | lld:pubmed |
| pubmed-article:2111585 | pubmed:author | pubmed-author:HiguchiD ADA | lld:pubmed |
| pubmed-article:2111585 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2111585 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:2111585 | pubmed:volume | 248 | lld:pubmed |
| pubmed-article:2111585 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2111585 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2111585 | pubmed:pagination | 1126-8 | lld:pubmed |
| pubmed-article:2111585 | pubmed:dateRevised | 2007-3-19 | lld:pubmed |
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| pubmed-article:2111585 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2111585 | pubmed:articleTitle | Platelet coagulation factor XIa-inhibitor, a form of Alzheimer amyloid precursor protein. | lld:pubmed |
| pubmed-article:2111585 | pubmed:affiliation | Department of Medicine, Jewish Hospital, Washington University Medical Center, St. Louis, MO 63110. | lld:pubmed |
| pubmed-article:2111585 | pubmed:publicationType | Journal Article | lld:pubmed |
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