| pubmed-article:21110974 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21110974 | lifeskim:mentions | umls-concept:C1326163 | lld:lifeskim |
| pubmed-article:21110974 | pubmed:issue | 24 | lld:pubmed |
| pubmed-article:21110974 | pubmed:dateCreated | 2010-12-7 | lld:pubmed |
| pubmed-article:21110974 | pubmed:abstractText | TCR-microclusters (MC) are generated upon TCR stimulation prior to the immune synapse formation independently of lipid rafts. TCR-MCs contain receptors, kinases and adaptors, and function as the signaling unit for T cell activation. The TCR complex, but not the signaling molecules, is transported to the center to form cSMAC. The co-stimulation receptor CD28 joins the signaling region of cSMAC and recruits PKC? and Carma1. CTLA-4 accumulates in the same region and competes with CD28 for negative regulation of T cell activation. T cell activation is therefore mediated by two spatially distinct signaling compartments: TCR signaling by the peripheral TCR-MC and co-stimulation signal by the central signaling cSMAC. | lld:pubmed |
| pubmed-article:21110974 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21110974 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21110974 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21110974 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21110974 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21110974 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:21110974 | pubmed:issn | 1873-3468 | lld:pubmed |
| pubmed-article:21110974 | pubmed:author | pubmed-author:SaitoTakashiT | lld:pubmed |
| pubmed-article:21110974 | pubmed:author | pubmed-author:YokosukaTadas... | lld:pubmed |
| pubmed-article:21110974 | pubmed:author | pubmed-author:Hashimoto-Tan... | lld:pubmed |
| pubmed-article:21110974 | pubmed:copyrightInfo | Copyright © 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. | lld:pubmed |
| pubmed-article:21110974 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21110974 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:21110974 | pubmed:volume | 584 | lld:pubmed |
| pubmed-article:21110974 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21110974 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21110974 | pubmed:pagination | 4865-71 | lld:pubmed |
| pubmed-article:21110974 | pubmed:meshHeading | pubmed-meshheading:21110974... | lld:pubmed |
| pubmed-article:21110974 | pubmed:meshHeading | pubmed-meshheading:21110974... | lld:pubmed |
| pubmed-article:21110974 | pubmed:meshHeading | pubmed-meshheading:21110974... | lld:pubmed |
| pubmed-article:21110974 | pubmed:meshHeading | pubmed-meshheading:21110974... | lld:pubmed |
| pubmed-article:21110974 | pubmed:meshHeading | pubmed-meshheading:21110974... | lld:pubmed |
| pubmed-article:21110974 | pubmed:meshHeading | pubmed-meshheading:21110974... | lld:pubmed |
| pubmed-article:21110974 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:21110974 | pubmed:articleTitle | Dynamic regulation of T cell activation and co-stimulation through TCR-microclusters. | lld:pubmed |
| pubmed-article:21110974 | pubmed:affiliation | Laboratory for Cell Signaling, RIKEN Research Center for Allergy and Immunology, Tsurumi-ku, Yokohama, Japan. saito@rcai.riken.jp | lld:pubmed |
| pubmed-article:21110974 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21110974 | pubmed:publicationType | Review | lld:pubmed |
