| pubmed-article:2110870 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2110870 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2110870 | lifeskim:mentions | umls-concept:C0008111 | lld:lifeskim |
| pubmed-article:2110870 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:2110870 | lifeskim:mentions | umls-concept:C0085080 | lld:lifeskim |
| pubmed-article:2110870 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:2110870 | lifeskim:mentions | umls-concept:C0032143 | lld:lifeskim |
| pubmed-article:2110870 | lifeskim:mentions | umls-concept:C0031327 | lld:lifeskim |
| pubmed-article:2110870 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2110870 | pubmed:dateCreated | 1990-6-21 | lld:pubmed |
| pubmed-article:2110870 | pubmed:abstractText | Pharmacokinetics of recombinant tissue-type plasminogen activator (rt-PA) produced in mouse C127 cells (t-PA(C127] and Chinese hamster ovary cells (t-PA(CHO] was investigated in chimpanzees. rt-PA was administered via a constant rate i.v. infusion for 60 min, and t-PA concentration and activity in plasma were measured during and after infusion. The noncompartmental parameters were calculated according to the moment analysis method, and a population pharmacokinetic analysis was performed to obtain the mean and interindividual variability of the pharmacokinetic parameters. The mean residence time of t-PA(C127) was significantly longer and the total body clearance was significantly less than that of t-PA(CHO). t-PA(C127) has an alpha-galactosyl moiety in its carbohydrate chains, whereas such a structure is not found in t-PA(CHO). These results demonstrate that two preparations of rt-PA's with different carbohydrate structures show different pharmacokinetics, and suggest that the carbohydrate structure can affect the efficiency of hepatic uptake of t-PA. A possible mechanism is an interaction of t-PA(C127) with the natural anti-alpha-galactosyl antibody. The anti-alpha-galactosyl antibody level in plasma decreased in association with the plasma levels of t-PA(C127) but was unaffected by t-PA(CHO) levels. | lld:pubmed |
| pubmed-article:2110870 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2110870 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2110870 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2110870 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2110870 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2110870 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2110870 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:2110870 | pubmed:issn | 0009-2363 | lld:pubmed |
| pubmed-article:2110870 | pubmed:author | pubmed-author:NomaSS | lld:pubmed |
| pubmed-article:2110870 | pubmed:author | pubmed-author:HoriRR | lld:pubmed |
| pubmed-article:2110870 | pubmed:author | pubmed-author:ShimizuNN | lld:pubmed |
| pubmed-article:2110870 | pubmed:author | pubmed-author:RichardsS MSM | lld:pubmed |
| pubmed-article:2110870 | pubmed:author | pubmed-author:OkumuraKK | lld:pubmed |
| pubmed-article:2110870 | pubmed:author | pubmed-author:SuzukiJJ | lld:pubmed |
| pubmed-article:2110870 | pubmed:author | pubmed-author:TsujiJJ | lld:pubmed |
| pubmed-article:2110870 | pubmed:author | pubmed-author:LivingstonD... | lld:pubmed |
| pubmed-article:2110870 | pubmed:author | pubmed-author:TanigawaraYY | lld:pubmed |
| pubmed-article:2110870 | pubmed:author | pubmed-author:KeyesL DLD | lld:pubmed |
| pubmed-article:2110870 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2110870 | pubmed:volume | 38 | lld:pubmed |
| pubmed-article:2110870 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2110870 | pubmed:authorsComplete | N | lld:pubmed |
| pubmed-article:2110870 | pubmed:pagination | 517-22 | lld:pubmed |
| pubmed-article:2110870 | pubmed:dateRevised | 2005-11-17 | lld:pubmed |
| pubmed-article:2110870 | pubmed:meshHeading | pubmed-meshheading:2110870-... | lld:pubmed |
| pubmed-article:2110870 | pubmed:meshHeading | pubmed-meshheading:2110870-... | lld:pubmed |
| pubmed-article:2110870 | pubmed:meshHeading | pubmed-meshheading:2110870-... | lld:pubmed |
| pubmed-article:2110870 | pubmed:meshHeading | pubmed-meshheading:2110870-... | lld:pubmed |
| pubmed-article:2110870 | pubmed:meshHeading | pubmed-meshheading:2110870-... | lld:pubmed |
| pubmed-article:2110870 | pubmed:meshHeading | pubmed-meshheading:2110870-... | lld:pubmed |
| pubmed-article:2110870 | pubmed:meshHeading | pubmed-meshheading:2110870-... | lld:pubmed |
| pubmed-article:2110870 | pubmed:meshHeading | pubmed-meshheading:2110870-... | lld:pubmed |
| pubmed-article:2110870 | pubmed:meshHeading | pubmed-meshheading:2110870-... | lld:pubmed |
| pubmed-article:2110870 | pubmed:meshHeading | pubmed-meshheading:2110870-... | lld:pubmed |
| pubmed-article:2110870 | pubmed:meshHeading | pubmed-meshheading:2110870-... | lld:pubmed |
| pubmed-article:2110870 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2110870 | pubmed:articleTitle | Pharmacokinetics in chimpanzees of recombinant human tissue-type plasminogen activator produced in mouse C127 and Chinese hamster ovary cells. | lld:pubmed |
| pubmed-article:2110870 | pubmed:affiliation | Department of Pharmacy, Kyoto University Hospital, Japan. | lld:pubmed |
| pubmed-article:2110870 | pubmed:publicationType | Journal Article | lld:pubmed |
