| pubmed-article:21107819 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21107819 | lifeskim:mentions | umls-concept:C1499123 | lld:lifeskim |
| pubmed-article:21107819 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:21107819 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:21107819 | lifeskim:mentions | umls-concept:C0025663 | lld:lifeskim |
| pubmed-article:21107819 | lifeskim:mentions | umls-concept:C0032105 | lld:lifeskim |
| pubmed-article:21107819 | lifeskim:mentions | umls-concept:C0680730 | lld:lifeskim |
| pubmed-article:21107819 | lifeskim:mentions | umls-concept:C0872318 | lld:lifeskim |
| pubmed-article:21107819 | lifeskim:mentions | umls-concept:C1148554 | lld:lifeskim |
| pubmed-article:21107819 | lifeskim:mentions | umls-concept:C0521115 | lld:lifeskim |
| pubmed-article:21107819 | lifeskim:mentions | umls-concept:C0600700 | lld:lifeskim |
| pubmed-article:21107819 | lifeskim:mentions | umls-concept:C1138465 | lld:lifeskim |
| pubmed-article:21107819 | lifeskim:mentions | umls-concept:C0332324 | lld:lifeskim |
| pubmed-article:21107819 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:21107819 | pubmed:dateCreated | 2011-1-11 | lld:pubmed |
| pubmed-article:21107819 | pubmed:abstractText | A liquid chromatography-mass spectrometry (LC-MS) method was developed and validated for the simultaneous determination of alisol A and alisol A 24-acetate from Alisma orientale (Sam.) Juz. in rat plasma using diazepam as an internal standard. A 200-?l plasma sample was extracted by methyl tert-butyl ether and the separation was performed on Kromasil C(18) column (150 × 4.6 mm, 5 ?m) with the mobile phase of acetonitrile (containing 0.1% of formic acid)-water (73:27, v/v) at a flow rate of 0.8 ml/min in a run time of 10 min. The two analytes were monitored with positive electrospray ionization by selected ion monitoring mode. The lower limit of quantitation for both alisol A and alisol A 24-acetate were 10 ng/ml. The calibration curves were linear in the measured range 10-1,000 ng/ml for alisol A and 10-500 ng/ml for alisol A 24-acetate. The mean extraction recoveries were above 74.7% for alisol A and above 72.4% for alisol A 24-acetate from biological matrixes. The intra- and inter-day precision for all concentrations of quality controls was lower than 14.1% (RSD %) for each analyte. The accuracy ranged from -12.3% to 9.8% (RE %) for alisol A, and -8.6% to 14.2% (RE %) for alisol A 24-acetate. The method was successfully applied to the study on the pharmacokinetics of alisol A and alisol A 24-acetate in rat plasma. | lld:pubmed |
| pubmed-article:21107819 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21107819 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21107819 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21107819 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21107819 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21107819 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21107819 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21107819 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:21107819 | pubmed:issn | 1618-2650 | lld:pubmed |
| pubmed-article:21107819 | pubmed:author | pubmed-author:StamJ WJW | lld:pubmed |
| pubmed-article:21107819 | pubmed:author | pubmed-author:ZoZ JZJ | lld:pubmed |
| pubmed-article:21107819 | pubmed:author | pubmed-author:BiKaishunK | lld:pubmed |
| pubmed-article:21107819 | pubmed:author | pubmed-author:YangGuoguangG | lld:pubmed |
| pubmed-article:21107819 | pubmed:author | pubmed-author:ChenXiaohuiX | lld:pubmed |
| pubmed-article:21107819 | pubmed:author | pubmed-author:YuYueY | lld:pubmed |
| pubmed-article:21107819 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21107819 | pubmed:volume | 399 | lld:pubmed |
| pubmed-article:21107819 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21107819 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21107819 | pubmed:pagination | 1363-9 | lld:pubmed |
| pubmed-article:21107819 | pubmed:meshHeading | pubmed-meshheading:21107819... | lld:pubmed |
| pubmed-article:21107819 | pubmed:meshHeading | pubmed-meshheading:21107819... | lld:pubmed |
| pubmed-article:21107819 | pubmed:meshHeading | pubmed-meshheading:21107819... | lld:pubmed |
| pubmed-article:21107819 | pubmed:meshHeading | pubmed-meshheading:21107819... | lld:pubmed |
| pubmed-article:21107819 | pubmed:meshHeading | pubmed-meshheading:21107819... | lld:pubmed |
| pubmed-article:21107819 | pubmed:meshHeading | pubmed-meshheading:21107819... | lld:pubmed |
| pubmed-article:21107819 | pubmed:meshHeading | pubmed-meshheading:21107819... | lld:pubmed |
| pubmed-article:21107819 | pubmed:meshHeading | pubmed-meshheading:21107819... | lld:pubmed |
| pubmed-article:21107819 | pubmed:meshHeading | pubmed-meshheading:21107819... | lld:pubmed |
| pubmed-article:21107819 | pubmed:meshHeading | pubmed-meshheading:21107819... | lld:pubmed |
| pubmed-article:21107819 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21107819 | pubmed:articleTitle | A sensitive liquid chromatography-mass spectrometry method for simultaneous determination of alisol A and alisol A 24-acetate from Alisma orientale (Sam.) Juz. in rat plasma. | lld:pubmed |
| pubmed-article:21107819 | pubmed:affiliation | Department of Pharmaceutical Analysis, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, China. | lld:pubmed |
| pubmed-article:21107819 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21107819 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
