| pubmed-article:21093329 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21093329 | lifeskim:mentions | umls-concept:C0021753 | lld:lifeskim |
| pubmed-article:21093329 | lifeskim:mentions | umls-concept:C0040994 | lld:lifeskim |
| pubmed-article:21093329 | lifeskim:mentions | umls-concept:C0020429 | lld:lifeskim |
| pubmed-article:21093329 | lifeskim:mentions | umls-concept:C0458247 | lld:lifeskim |
| pubmed-article:21093329 | lifeskim:mentions | umls-concept:C0161406 | lld:lifeskim |
| pubmed-article:21093329 | lifeskim:mentions | umls-concept:C1880177 | lld:lifeskim |
| pubmed-article:21093329 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:21093329 | pubmed:dateCreated | 2011-5-16 | lld:pubmed |
| pubmed-article:21093329 | pubmed:abstractText | It has been reported that the whisker pad (WP) area, which is innervated by the second branch of the trigeminal nerve, shows allodynia/hyperalgesia following transection of the mental nerve (MN: the third branch of the trigeminal nerve). However, the mechanisms of this extra-territorial pain induction still remain unclear. Glia and cytokines are known to facilitate perception of noxious input, raising a possibility that these non-neuronal elements are involved in the induction and spread of allodynia/hyperalgesia at non-injured skin territory. One day after MN transection, tactile allodynia/hyperalgesia developed on the ipsilateral WP area, which is in the non-injured skin territory. The tactile allodynia/hyperalgesia lasted for more than 56 days. In response to MN transection, astrocytes and microglia appeared to be in an activated state, and interleukin (IL)-1beta was up-regulated in astrocytes in the trigeminal subnucleus caudalis (Vc). Allodynia/hyperalgesia at WP area induced by MN transection was attenuated dose-dependently by IL-1 receptor antagonist IL-1ra (i.t., 0.05, 0.5, and 5 pg/rat). Fos-like immunoreactive (Fos-Li) neurons were observed in the Vc after non-noxious mechanical stimulation of the WP area in the rats with MN transection. Administration of IL-1ra also attenuated the number of Fos-Li neurons dose-dependently. Administration of a noncompetitive antagonist of NMDA receptors MK-801 (i.t., 5 ?g/rat) reversed allodynia/hyperalgesia. IL-1 receptor type I (IL-1RI) was localized in Fos- and phospho NR1-immunoreactive neurons. These results suggest that IL-1beta in the Vc plays an important role in the development of extra-territorial tactile allodynia/hyperalgesia after MN transection. | lld:pubmed |
| pubmed-article:21093329 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21093329 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21093329 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21093329 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21093329 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21093329 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21093329 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21093329 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21093329 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21093329 | pubmed:month | May | lld:pubmed |
| pubmed-article:21093329 | pubmed:issn | 1532-2149 | lld:pubmed |
| pubmed-article:21093329 | pubmed:author | pubmed-author:WatanabeMineo... | lld:pubmed |
| pubmed-article:21093329 | pubmed:author | pubmed-author:TanneKazuoK | lld:pubmed |
| pubmed-article:21093329 | pubmed:author | pubmed-author:UchidaTakashi... | lld:pubmed |
| pubmed-article:21093329 | pubmed:author | pubmed-author:TakahashiKouj... | lld:pubmed |
| pubmed-article:21093329 | pubmed:author | pubmed-author:HiyamaShinjiS | lld:pubmed |
| pubmed-article:21093329 | pubmed:author | pubmed-author:SuekawaYoheiY | lld:pubmed |
| pubmed-article:21093329 | pubmed:author | pubmed-author:InubushiToshi... | lld:pubmed |
| pubmed-article:21093329 | pubmed:author | pubmed-author:ItoGoshiG | lld:pubmed |
| pubmed-article:21093329 | pubmed:author | pubmed-author:HiroseNaotoN | lld:pubmed |
| pubmed-article:21093329 | pubmed:author | pubmed-author:MurasakiKyoko... | lld:pubmed |
| pubmed-article:21093329 | pubmed:copyrightInfo | Copyright © 2010 European Federation of International Association for the Study of Pain Chapters. Published by Elsevier Ltd. All rights reserved. | lld:pubmed |
| pubmed-article:21093329 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21093329 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:21093329 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21093329 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21093329 | pubmed:pagination | 467.e1-14 | lld:pubmed |
| pubmed-article:21093329 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:21093329 | pubmed:meshHeading | pubmed-meshheading:21093329... | lld:pubmed |
| pubmed-article:21093329 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21093329 | pubmed:articleTitle | IL-1beta in the trigeminal subnucleus caudalis contributes to extra-territorial allodynia/hyperalgesia following a trigeminal nerve injury. | lld:pubmed |
| pubmed-article:21093329 | pubmed:affiliation | Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate School of Biomedical Science, Kasumi 1-2-3, Minami-ku, Hiroshima 734-8553, Japan. | lld:pubmed |
| pubmed-article:21093329 | pubmed:publicationType | Journal Article | lld:pubmed |
| entrez-gene:24494 | entrezgene:pubmed | pubmed-article:21093329 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21093329 | lld:entrezgene |
