| pubmed-article:21093258 | pubmed:abstractText | The synthesis and SAR of a series of 4,4-disubstituted cyclohexylbenzamide inhibitors of 11?-HSD1 are described. Optimization rapidly led to potent, highly selective, and orally bioavailable inhibitors demonstrating efficacy in both rat and non-human primate ex vivo pharmacodynamic models. | lld:pubmed |
