| pubmed-article:21092110 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21092110 | lifeskim:mentions | umls-concept:C0026339 | lld:lifeskim |
| pubmed-article:21092110 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:21092110 | lifeskim:mentions | umls-concept:C1882071 | lld:lifeskim |
| pubmed-article:21092110 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:21092110 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:21092110 | lifeskim:mentions | umls-concept:C1511726 | lld:lifeskim |
| pubmed-article:21092110 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:21092110 | lifeskim:mentions | umls-concept:C1413709 | lld:lifeskim |
| pubmed-article:21092110 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:21092110 | lifeskim:mentions | umls-concept:C0457083 | lld:lifeskim |
| pubmed-article:21092110 | lifeskim:mentions | umls-concept:C1517503 | lld:lifeskim |
| pubmed-article:21092110 | pubmed:dateCreated | 2010-12-17 | lld:pubmed |
| pubmed-article:21092110 | pubmed:abstractText | Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis is a hallmark of complex and multifactorial psychiatric diseases such as anxiety and mood disorders. About 50-60% of patients with major depression show HPA axis dysfunction, i.e. hyperactivity and impaired negative feedback regulation. The neuropeptide corticotropin-releasing hormone (CRH) and its receptor type 1 (CRHR1) are key regulators of this neuroendocrine stress axis. Therefore, we analyzed CRH/CRHR1-dependent gene expression data obtained from the pituitary corticotrope cell line AtT-20, a well-established in vitro model for CRHR1-mediated signal transduction. To extract significantly regulated genes from a genome-wide microarray data set and to deduce underlying CRHR1-dependent signaling networks, we combined supervised and unsupervised algorithms. | lld:pubmed |
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| pubmed-article:21092110 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21092110 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21092110 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21092110 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21092110 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21092110 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21092110 | pubmed:issn | 1752-0509 | lld:pubmed |
| pubmed-article:21092110 | pubmed:author | pubmed-author:HolsboerFlori... | lld:pubmed |
| pubmed-article:21092110 | pubmed:author | pubmed-author:WurstWolfgang... | lld:pubmed |
| pubmed-article:21092110 | pubmed:author | pubmed-author:WeberPeterP | lld:pubmed |
| pubmed-article:21092110 | pubmed:author | pubmed-author:WelzlGerhardG | lld:pubmed |
| pubmed-article:21092110 | pubmed:author | pubmed-author:PützBennoB | lld:pubmed |
| pubmed-article:21092110 | pubmed:author | pubmed-author:DeussingJan... | lld:pubmed |
| pubmed-article:21092110 | pubmed:author | pubmed-author:GrafCorneliaC | lld:pubmed |
| pubmed-article:21092110 | pubmed:author | pubmed-author:KühneClaudiaC | lld:pubmed |
| pubmed-article:21092110 | pubmed:author | pubmed-author:TrümbachDietr... | lld:pubmed |
| pubmed-article:21092110 | pubmed:author | pubmed-author:PanhuysenMarc... | lld:pubmed |
| pubmed-article:21092110 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21092110 | pubmed:volume | 4 | lld:pubmed |
| pubmed-article:21092110 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21092110 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21092110 | pubmed:pagination | 159 | lld:pubmed |
| pubmed-article:21092110 | pubmed:dateRevised | 2011-7-20 | lld:pubmed |
| pubmed-article:21092110 | pubmed:meshHeading | pubmed-meshheading:21092110... | lld:pubmed |
| pubmed-article:21092110 | pubmed:meshHeading | pubmed-meshheading:21092110... | lld:pubmed |
| pubmed-article:21092110 | pubmed:meshHeading | pubmed-meshheading:21092110... | lld:pubmed |
| pubmed-article:21092110 | pubmed:meshHeading | pubmed-meshheading:21092110... | lld:pubmed |
