Linked Life Data

21075611

Source:http://linkedlifedata.com/resource/pubmed/id/21075611

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pubmed-article:21075611pubmed:abstractTextTranscriptome analyses were performed in the anterior raphe area of mutant mice deficient in the serotonin transporter (5-HTT KO) or overexpressing this protein (5-HTT TG), which exhibit opposite changes in anxiety-related behavior. Among genes with altered expression, the gene encoding the neuropeptide urocortin 1 was down-regulated in 5-HTT KO and up-regulated in 5-HTT TG mice. Expression of the gene encoding cocaine-and-amphetamine-related-peptide, which colocalizes with urocortin 1, was also increased in 5-HTT TG mutants. Real-time RT-PCR confirmed these data and immunoautoradiographic labeling showed that parallel changes in neuropeptide levels were confined to the non-preganglionic Edinger-Westphal nucleus. Thus, 5-HTT expression correlates with that of urocortin 1, suggesting that this peptide can be involved in the behavioral changes observed in 5-HTT mutant mice.lld:pubmed
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pubmed-article:21075611pubmed:copyrightInfoCopyright © 2010 Elsevier B.V. and ECNP. All rights reserved.lld:pubmed
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pubmed-article:21075611pubmed:year2011lld:pubmed
pubmed-article:21075611pubmed:articleTitleDifferential gene expression in mutant mice overexpressing or deficient in the serotonin transporter: a focus on urocortin 1.lld:pubmed
pubmed-article:21075611pubmed:affiliationUniversité Pierre et Marie Curie-Paris6, Faculté de Médecine Pierre et Marie Curie, Site Pitié-Salpêtrière, IFR 70 des Neurosciences, UMR S677, Paris, F-75013, France. veronique.fabre@upmc.frlld:pubmed
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