| pubmed-article:21072873 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21072873 | lifeskim:mentions | umls-concept:C0020967 | lld:lifeskim |
| pubmed-article:21072873 | lifeskim:mentions | umls-concept:C0016194 | lld:lifeskim |
| pubmed-article:21072873 | lifeskim:mentions | umls-concept:C0033414 | lld:lifeskim |
| pubmed-article:21072873 | lifeskim:mentions | umls-concept:C1336637 | lld:lifeskim |
| pubmed-article:21072873 | lifeskim:mentions | umls-concept:C1826433 | lld:lifeskim |
| pubmed-article:21072873 | lifeskim:mentions | umls-concept:C0205410 | lld:lifeskim |
| pubmed-article:21072873 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:21072873 | pubmed:dateCreated | 2010-11-26 | lld:pubmed |
| pubmed-article:21072873 | pubmed:abstractText | The fact that some TLR-based vaccine adjuvants maintain function in TLR-deficient hosts highlights that their mechanism of function remains incompletely understood. Thus, we examined the ability of flagellin to induce cytokines and elicit/promote murine antibody responses upon deletion of the flagellin receptors TLR5 and/or NLRC4 (also referred to as IPAF) using a prime/boost regimen. In TLR5-KO mice, flagellin failed to induce NF-?B-regulated cytokines such as keratinocyte-derived chemokine (CXCL1) but induced WT levels of the inflammasome cytokine IL-18 (IL-1F4). Conversely, in NLRC4-KO mice, flagellin induced keratinocyte-derived chemokine, but not IL-18, whereas TLR5/NLRC4-DKO lacked induction of all cytokines measured. Flagellin/ovalbumin treatment resulted in high-antibody titers to both flagellin and ovalbumin in WT, TLR5-KO and DKO mice but did not elicit antibodies to either in TLR5/NLRC4-DKO mice. Thus, flagellin's ability to elicit/promote humoral immunity requires a germ-line-encoded receptor capable of recognizing this molecule. Such promotion of adaptive immunity can be effectively driven by either TLR5-mediated activation of NF-?B or NLRC4-mediated activation of the inflammasome. | lld:pubmed |
| pubmed-article:21072873 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21072873 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21072873 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21072873 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21072873 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21072873 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21072873 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21072873 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21072873 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21072873 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21072873 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21072873 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21072873 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21072873 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21072873 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21072873 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21072873 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21072873 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21072873 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:21072873 | pubmed:issn | 1521-4141 | lld:pubmed |
| pubmed-article:21072873 | pubmed:author | pubmed-author:GewirtzAndrew... | lld:pubmed |
| pubmed-article:21072873 | pubmed:author | pubmed-author:Vijay-KumarMa... | lld:pubmed |
| pubmed-article:21072873 | pubmed:author | pubmed-author:FifadaraNimit... | lld:pubmed |
| pubmed-article:21072873 | pubmed:author | pubmed-author:AitkenJesse... | lld:pubmed |
| pubmed-article:21072873 | pubmed:author | pubmed-author:CarvalhoFrede... | lld:pubmed |
| pubmed-article:21072873 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21072873 | pubmed:volume | 40 | lld:pubmed |
| pubmed-article:21072873 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21072873 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21072873 | pubmed:pagination | 3528-34 | lld:pubmed |
| pubmed-article:21072873 | pubmed:dateRevised | 2011-5-18 | lld:pubmed |
| pubmed-article:21072873 | pubmed:meshHeading | pubmed-meshheading:21072873... | lld:pubmed |
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| pubmed-article:21072873 | pubmed:meshHeading | pubmed-meshheading:21072873... | lld:pubmed |
| pubmed-article:21072873 | pubmed:meshHeading | pubmed-meshheading:21072873... | lld:pubmed |
| pubmed-article:21072873 | pubmed:meshHeading | pubmed-meshheading:21072873... | lld:pubmed |
| pubmed-article:21072873 | pubmed:meshHeading | pubmed-meshheading:21072873... | lld:pubmed |
| pubmed-article:21072873 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:21072873 | pubmed:articleTitle | TLR5 or NLRC4 is necessary and sufficient for promotion of humoral immunity by flagellin. | lld:pubmed |
| pubmed-article:21072873 | pubmed:affiliation | Department of Pathology, Emory University, Atlanta, GA 30322, USA. | lld:pubmed |
| pubmed-article:21072873 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21072873 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:21072873 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:53791 | entrezgene:pubmed | pubmed-article:21072873 | lld:entrezgene |
| entrez-gene:268973 | entrezgene:pubmed | pubmed-article:21072873 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:21072873 | lld:pubmed |
