| pubmed-article:2106348 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2106348 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:2106348 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2106348 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
| pubmed-article:2106348 | lifeskim:mentions | umls-concept:C1879725 | lld:lifeskim |
| pubmed-article:2106348 | lifeskim:mentions | umls-concept:C1158360 | lld:lifeskim |
| pubmed-article:2106348 | lifeskim:mentions | umls-concept:C0205349 | lld:lifeskim |
| pubmed-article:2106348 | lifeskim:mentions | umls-concept:C1511938 | lld:lifeskim |
| pubmed-article:2106348 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2106348 | pubmed:dateCreated | 1990-4-6 | lld:pubmed |
| pubmed-article:2106348 | pubmed:abstractText | The human cell line U937 was used as a model for differentiation along the mononuclear phagocyte lineage. Following treatment with the phorbol ester TPA, PGE2 and TxB2 secretion was induced 50-100-fold, and both PGF2 alpha and PGI2 levels became detectable in the supernatant of TPA-differentiated U937 cells. The content of the prostaglandin precursor, arachidonic acid, remained unchanged in the cellular phospholipids of undifferentiated and TPA-differentiated U937 cells. Of the enzymes involved in the availability and metabolism of arachidonic acid, phospholipase A2 activity was increased 2-fold in the membranes of TPA-differentiated U937 cells, whereas lysophosphatide acyltransferase activity remained unaltered. Cyclooxygenase activity, however, was enhanced 5-10-fold, which was due to enhanced expression of the enzyme as demonstrated by dot-blot analysis. The data suggest that the capacity to secrete prostaglandins is acquired during differentiation with TPA and results mainly from an increased cyclooxygenase activity. Despite the capacity of TPA-differentiated U937 cells to synthesize prostaglandins, none of the known monocytic stimuli further stimulated prostaglandin secretion in TPA-differentiated U937 cells. Generation of leukotrienes appears to represent a later state in the differentiation along the monocyte-macrophage lineage, since neither LTB4 nor cysteinyl-leukotrienes were detectable in the supernatants of either undifferentiated or TPA-differentiated U937 cells. | lld:pubmed |
| pubmed-article:2106348 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2106348 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2106348 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2106348 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2106348 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2106348 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:2106348 | pubmed:issn | 0006-3002 | lld:pubmed |
| pubmed-article:2106348 | pubmed:author | pubmed-author:ReschKK | lld:pubmed |
| pubmed-article:2106348 | pubmed:author | pubmed-author:WesselKK | lld:pubmed |
| pubmed-article:2106348 | pubmed:author | pubmed-author:HassRR | lld:pubmed |
| pubmed-article:2106348 | pubmed:author | pubmed-author:DeWittD LDL | lld:pubmed |
| pubmed-article:2106348 | pubmed:author | pubmed-author:KaeverVV | lld:pubmed |
| pubmed-article:2106348 | pubmed:author | pubmed-author:Goppelt-Strue... | lld:pubmed |
| pubmed-article:2106348 | pubmed:author | pubmed-author:KoehlerLL | lld:pubmed |
| pubmed-article:2106348 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2106348 | pubmed:day | 23 | lld:pubmed |
| pubmed-article:2106348 | pubmed:volume | 1042 | lld:pubmed |
| pubmed-article:2106348 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2106348 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2106348 | pubmed:pagination | 395-403 | lld:pubmed |
| pubmed-article:2106348 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:2106348 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2106348 | pubmed:articleTitle | Altered arachidonic acid metabolism during differentiation of the human monoblastoid cell line U937. | lld:pubmed |
| pubmed-article:2106348 | pubmed:affiliation | Department of Pharmacology and Toxicology, Medical School Hannover, F.R.G. | lld:pubmed |
| pubmed-article:2106348 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2106348 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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