| pubmed-article:21056990 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21056990 | lifeskim:mentions | umls-concept:C1522604 | lld:lifeskim |
| pubmed-article:21056990 | lifeskim:mentions | umls-concept:C0027627 | lld:lifeskim |
| pubmed-article:21056990 | lifeskim:mentions | umls-concept:C1513095 | lld:lifeskim |
| pubmed-article:21056990 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:21056990 | lifeskim:mentions | umls-concept:C1522484 | lld:lifeskim |
| pubmed-article:21056990 | lifeskim:mentions | umls-concept:C0036525 | lld:lifeskim |
| pubmed-article:21056990 | lifeskim:mentions | umls-concept:C1332823 | lld:lifeskim |
| pubmed-article:21056990 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:21056990 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:21056990 | pubmed:issue | 24 | lld:pubmed |
| pubmed-article:21056990 | pubmed:dateCreated | 2010-12-16 | lld:pubmed |
| pubmed-article:21056990 | pubmed:abstractText | Highly metastatic and chemotherapy-resistant properties of malignant melanomas stand as challenging barriers to successful treatment; yet, the mechanisms responsible for their aggressive characteristics are not fully defined. We show that a distinct population expressing CD133 (Prominin-1), which is highly enriched after administration of a chemotherapeutic drug, dacarbazine, has enhanced metastatic potential in vivo. CD133(+) tumor cells are located close to tumor-associated lymphatic vessels in metastatic organs such as the regional lymph nodes and lung. Lymphatic endothelial cells promote the migratory activity of a CD133(+) subset to target organs and regulation of lymphatic growth efficiently modulates the metastasis of CD133(+) tumor cells. We found that lymphatic vessels in metastatic tissues stimulate chemokine receptor 4 (CXCR4)(+)/CD133(+) cell metastasis to target organs by secretion of stromal cell-derived factor-1 (SDF-1). The CXCR4(+)/CD133(+) cells exhibited higher metastatic activity compared with CXCR4(-)/CD133(+) cells and, importantly, blockade of CXCR4 coupled with dacarbazine efficiently inhibited both tumor growth and metastasis; dacarbazine alone could not attenuate tumor metastasis. The current study demonstrates a previously unidentified role of the lymphatic microenvironment in facilitating metastasis of chemoresistant melanoma cells via a specific chemotactic axis, SDF-1/CXCR4. Our findings suggest that targeting the SDF-1/CXCR4 axis in addition to dacarbazine treatment could therapeutically block chemoresistant CD133(+) cell metastasis toward a lymphatic metastatic niche. | lld:pubmed |
| pubmed-article:21056990 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21056990 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21056990 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21056990 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21056990 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21056990 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21056990 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21056990 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21056990 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21056990 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21056990 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21056990 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21056990 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21056990 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21056990 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21056990 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:21056990 | pubmed:issn | 1538-7445 | lld:pubmed |
| pubmed-article:21056990 | pubmed:author | pubmed-author:KimInjuneI | lld:pubmed |
| pubmed-article:21056990 | pubmed:author | pubmed-author:KohGou... | lld:pubmed |
| pubmed-article:21056990 | pubmed:author | pubmed-author:AlitaloKariK | lld:pubmed |
| pubmed-article:21056990 | pubmed:author | pubmed-author:KimMinahM | lld:pubmed |
| pubmed-article:21056990 | pubmed:author | pubmed-author:NamDo-HyunDH | lld:pubmed |
| pubmed-article:21056990 | pubmed:author | pubmed-author:KimKyung... | lld:pubmed |
| pubmed-article:21056990 | pubmed:author | pubmed-author:KohYoung... | lld:pubmed |
| pubmed-article:21056990 | pubmed:author | pubmed-author:KohBong IhnBI | lld:pubmed |
| pubmed-article:21056990 | pubmed:copyrightInfo | ©2010 AACR. | lld:pubmed |
| pubmed-article:21056990 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21056990 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:21056990 | pubmed:volume | 70 | lld:pubmed |
| pubmed-article:21056990 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21056990 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21056990 | pubmed:pagination | 10411-21 | lld:pubmed |
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| pubmed-article:21056990 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:21056990 | pubmed:articleTitle | CXCR4 signaling regulates metastasis of chemoresistant melanoma cells by a lymphatic metastatic niche. | lld:pubmed |
| pubmed-article:21056990 | pubmed:affiliation | National Research Laboratory of Vascular Biology and Stem Cells, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea. | lld:pubmed |
| pubmed-article:21056990 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21056990 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
