| pubmed-article:21055985 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21055985 | lifeskim:mentions | umls-concept:C0024660 | lld:lifeskim |
| pubmed-article:21055985 | lifeskim:mentions | umls-concept:C0006812 | lld:lifeskim |
| pubmed-article:21055985 | lifeskim:mentions | umls-concept:C0312418 | lld:lifeskim |
| pubmed-article:21055985 | lifeskim:mentions | umls-concept:C0430054 | lld:lifeskim |
| pubmed-article:21055985 | lifeskim:mentions | umls-concept:C1257825 | lld:lifeskim |
| pubmed-article:21055985 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:21055985 | lifeskim:mentions | umls-concept:C1705053 | lld:lifeskim |
| pubmed-article:21055985 | lifeskim:mentions | umls-concept:C0036667 | lld:lifeskim |
| pubmed-article:21055985 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:21055985 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:21055985 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:21055985 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:21055985 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:21055985 | pubmed:dateCreated | 2010-11-24 | lld:pubmed |
| pubmed-article:21055985 | pubmed:abstractText | Replication stress involving collision of replisomes with camptothecin (CPT)-stabilized DNA-Topoisomerase I adducts activates an ATR-dependent pathway to promote repair by homologous recombination. To identify human genes that protect cells from such replication stress, we performed a genome-wide CPT sensitivity screen. Among numerous candidate genes are two previously unstudied proteins: the ankyrin repeat protein NFKBIL2 and C6ORF167 (MMS22L), distantly related to yeast replication stress regulator Mms22p. MMS22L and NFKBIL2 interact with each other and with FACT (facilitator of chromatin transcription) and MCM (minichromosome maintenance) complexes. Cells depleted of NFKBIL2 or MMS22L are sensitive to DNA-damaging agents, load phosphorylated RPA onto chromatin in a CTIP-dependent manner, activate the ATR/ATRIP-CHK1 and double-strand break repair signaling pathways, and are defective in HR. This study identifies MMS22L-NFKBIL2 as components of the replication stress control pathway and provides a resource for discovery of additional components of this pathway. | lld:pubmed |
| pubmed-article:21055985 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21055985 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21055985 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21055985 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21055985 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21055985 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21055985 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21055985 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21055985 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21055985 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21055985 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21055985 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21055985 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21055985 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21055985 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21055985 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21055985 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21055985 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21055985 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21055985 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21055985 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21055985 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21055985 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21055985 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21055985 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21055985 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21055985 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21055985 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21055985 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21055985 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:21055985 | pubmed:issn | 1097-4164 | lld:pubmed |
| pubmed-article:21055985 | pubmed:author | pubmed-author:ElledgeStephe... | lld:pubmed |
| pubmed-article:21055985 | pubmed:author | pubmed-author:SowaMathew... | lld:pubmed |
| pubmed-article:21055985 | pubmed:author | pubmed-author:HarperJ... | lld:pubmed |
| pubmed-article:21055985 | pubmed:author | pubmed-author:GygiSteven... | lld:pubmed |
| pubmed-article:21055985 | pubmed:author | pubmed-author:SchlabachMich... | lld:pubmed |
| pubmed-article:21055985 | pubmed:author | pubmed-author:O'ConnellBren... | lld:pubmed |
| pubmed-article:21055985 | pubmed:author | pubmed-author:CicciaAlberto... | lld:pubmed |
| pubmed-article:21055985 | pubmed:author | pubmed-author:BredemeyerAnd... | lld:pubmed |
| pubmed-article:21055985 | pubmed:author | pubmed-author:LydeardJohn... | lld:pubmed |
| pubmed-article:21055985 | pubmed:author | pubmed-author:AdamsonBrittB | lld:pubmed |
| pubmed-article:21055985 | pubmed:copyrightInfo | Copyright © 2010 Elsevier Inc. All rights reserved. | lld:pubmed |
| pubmed-article:21055985 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21055985 | pubmed:day | 24 | lld:pubmed |
| pubmed-article:21055985 | pubmed:volume | 40 | lld:pubmed |
| pubmed-article:21055985 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21055985 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21055985 | pubmed:pagination | 645-57 | lld:pubmed |
| pubmed-article:21055985 | pubmed:dateRevised | 2011-10-6 | lld:pubmed |
| pubmed-article:21055985 | pubmed:meshHeading | pubmed-meshheading:21055985... | lld:pubmed |
| pubmed-article:21055985 | pubmed:meshHeading | pubmed-meshheading:21055985... | lld:pubmed |
| pubmed-article:21055985 | pubmed:meshHeading | pubmed-meshheading:21055985... | lld:pubmed |
| pubmed-article:21055985 | pubmed:meshHeading | pubmed-meshheading:21055985... | lld:pubmed |
| pubmed-article:21055985 | pubmed:meshHeading | pubmed-meshheading:21055985... | lld:pubmed |
| pubmed-article:21055985 | pubmed:meshHeading | pubmed-meshheading:21055985... | lld:pubmed |
| pubmed-article:21055985 | pubmed:meshHeading | pubmed-meshheading:21055985... | lld:pubmed |
| pubmed-article:21055985 | pubmed:meshHeading | pubmed-meshheading:21055985... | lld:pubmed |
| pubmed-article:21055985 | pubmed:meshHeading | pubmed-meshheading:21055985... | lld:pubmed |
| pubmed-article:21055985 | pubmed:meshHeading | pubmed-meshheading:21055985... | lld:pubmed |
| pubmed-article:21055985 | pubmed:meshHeading | pubmed-meshheading:21055985... | lld:pubmed |
| pubmed-article:21055985 | pubmed:meshHeading | pubmed-meshheading:21055985... | lld:pubmed |
| pubmed-article:21055985 | pubmed:meshHeading | pubmed-meshheading:21055985... | lld:pubmed |
| pubmed-article:21055985 | pubmed:meshHeading | pubmed-meshheading:21055985... | lld:pubmed |
| pubmed-article:21055985 | pubmed:meshHeading | pubmed-meshheading:21055985... | lld:pubmed |
| pubmed-article:21055985 | pubmed:meshHeading | pubmed-meshheading:21055985... | lld:pubmed |
| pubmed-article:21055985 | pubmed:meshHeading | pubmed-meshheading:21055985... | lld:pubmed |
| pubmed-article:21055985 | pubmed:meshHeading | pubmed-meshheading:21055985... | lld:pubmed |
| pubmed-article:21055985 | pubmed:meshHeading | pubmed-meshheading:21055985... | lld:pubmed |
| pubmed-article:21055985 | pubmed:meshHeading | pubmed-meshheading:21055985... | lld:pubmed |
| pubmed-article:21055985 | pubmed:meshHeading | pubmed-meshheading:21055985... | lld:pubmed |
| pubmed-article:21055985 | pubmed:meshHeading | pubmed-meshheading:21055985... | lld:pubmed |
| pubmed-article:21055985 | pubmed:meshHeading | pubmed-meshheading:21055985... | lld:pubmed |
| pubmed-article:21055985 | pubmed:meshHeading | pubmed-meshheading:21055985... | lld:pubmed |
| pubmed-article:21055985 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:21055985 | pubmed:articleTitle | A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability. | lld:pubmed |
| pubmed-article:21055985 | pubmed:affiliation | Department of Pathology, Harvard Medical School, Boston, MA 02115, USA. | lld:pubmed |
| pubmed-article:21055985 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21055985 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:21055985 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:4171 | entrezgene:pubmed | pubmed-article:21055985 | lld:entrezgene |
| entrez-gene:4172 | entrezgene:pubmed | pubmed-article:21055985 | lld:entrezgene |
| entrez-gene:4173 | entrezgene:pubmed | pubmed-article:21055985 | lld:entrezgene |
| entrez-gene:4174 | entrezgene:pubmed | pubmed-article:21055985 | lld:entrezgene |
| entrez-gene:4175 | entrezgene:pubmed | pubmed-article:21055985 | lld:entrezgene |
| entrez-gene:4796 | entrezgene:pubmed | pubmed-article:21055985 | lld:entrezgene |
| entrez-gene:6749 | entrezgene:pubmed | pubmed-article:21055985 | lld:entrezgene |
| entrez-gene:11198 | entrezgene:pubmed | pubmed-article:21055985 | lld:entrezgene |
| entrez-gene:253714 | entrezgene:pubmed | pubmed-article:21055985 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21055985 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21055985 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21055985 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21055985 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21055985 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21055985 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21055985 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21055985 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21055985 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21055985 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21055985 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21055985 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21055985 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21055985 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21055985 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21055985 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21055985 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21055985 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21055985 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21055985 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21055985 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21055985 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21055985 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21055985 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21055985 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21055985 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21055985 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21055985 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21055985 | lld:entrezgene |
