| pubmed-article:21054788 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21054788 | lifeskim:mentions | umls-concept:C0205145 | lld:lifeskim |
| pubmed-article:21054788 | lifeskim:mentions | umls-concept:C0036720 | lld:lifeskim |
| pubmed-article:21054788 | lifeskim:mentions | umls-concept:C0065661 | lld:lifeskim |
| pubmed-article:21054788 | lifeskim:mentions | umls-concept:C1416912 | lld:lifeskim |
| pubmed-article:21054788 | pubmed:issue | 23 | lld:pubmed |
| pubmed-article:21054788 | pubmed:dateCreated | 2010-11-16 | lld:pubmed |
| pubmed-article:21054788 | pubmed:abstractText | CD91 plays an important role in the scavenging of apoptotic material, possibly through binding to soluble pattern-recognition molecules. In this study, we investigated the interaction of CD91 with mannan-binding lectin (MBL), ficolins and lung surfactant proteins. Both MBL and L-ficolin were found to bind CD91. The MBL-CD91 interaction was time- and concentration-dependent and could be inhibited by known ligands of CD91. MBL-associated serine protease 3 (MASP-3) also inhibited binding between MBL and CD91, suggesting that the site of interaction is located at or near the MASP-MBL interaction site. This was confirmed by using MBL mutants deficient for MASP binding that were unable to interact with CD91. These findings demonstrate that MBL and L-ficolin interact with CD91, strongly suggesting that they have the potential to function as soluble recognition molecules for scavenging microbial and apoptotic material by CD91. | lld:pubmed |
| pubmed-article:21054788 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21054788 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21054788 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21054788 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:21054788 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21054788 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:21054788 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21054788 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21054788 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:21054788 | pubmed:issn | 1742-4658 | lld:pubmed |
| pubmed-article:21054788 | pubmed:author | pubmed-author:LacroixMoniqu... | lld:pubmed |
| pubmed-article:21054788 | pubmed:author | pubmed-author:ThielensNicol... | lld:pubmed |
| pubmed-article:21054788 | pubmed:author | pubmed-author:HouenGunnarG | lld:pubmed |
| pubmed-article:21054788 | pubmed:author | pubmed-author:HolmskovUffeU | lld:pubmed |
| pubmed-article:21054788 | pubmed:author | pubmed-author:FrachetPhilip... | lld:pubmed |
| pubmed-article:21054788 | pubmed:author | pubmed-author:DuusKarenK | lld:pubmed |
| pubmed-article:21054788 | pubmed:author | pubmed-author:TacnetPascale... | lld:pubmed |
| pubmed-article:21054788 | pubmed:copyrightInfo | © 2010 The Authors Journal compilation © 2010 FEBS. | lld:pubmed |
| pubmed-article:21054788 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21054788 | pubmed:volume | 277 | lld:pubmed |
| pubmed-article:21054788 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21054788 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21054788 | pubmed:pagination | 4956-64 | lld:pubmed |
| pubmed-article:21054788 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:21054788 | pubmed:meshHeading | pubmed-meshheading:21054788... | lld:pubmed |
| pubmed-article:21054788 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:21054788 | pubmed:articleTitle | CD91 interacts with mannan-binding lectin (MBL) through the MBL-associated serine protease-binding site. | lld:pubmed |
| pubmed-article:21054788 | pubmed:affiliation | Department of Clinical Biochemistry and Immunology, Statens Serum Institut, Artillerivej 5, Copenhagen, Denmark. kds@ssi.dk | lld:pubmed |
| pubmed-article:21054788 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21054788 | pubmed:publicationType | In Vitro | lld:pubmed |
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