| pubmed-article:2105169 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2105169 | lifeskim:mentions | umls-concept:C0021758 | lld:lifeskim |
| pubmed-article:2105169 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:2105169 | lifeskim:mentions | umls-concept:C0009013 | lld:lifeskim |
| pubmed-article:2105169 | lifeskim:mentions | umls-concept:C0483191 | lld:lifeskim |
| pubmed-article:2105169 | lifeskim:mentions | umls-concept:C0376249 | lld:lifeskim |
| pubmed-article:2105169 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:2105169 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2105169 | pubmed:dateCreated | 1990-3-14 | lld:pubmed |
| pubmed-article:2105169 | pubmed:abstractText | The coexpression of both CD4 and CD8 molecules on T cells occurs in the peripheral blood at a low frequency and can be generated transiently on CD4+ peripheral blood T cells by treatment with lectin which induces CD8 biosynthesis and cell surface expression. We have cloned T cells in a nonselective fashion from normal subjects in the presence of either IL-2, rIL-4 and IL-2, or rIL-4 and have examined the phenotypic expression of CD4 and CD8. The addition of excess rIL-4 increased the expression of CD8 on the surface of CD4+ T cell clones but did not increase CD4 expression on CD8+ T cell clones. There were three patterns of CD4 and CD8 expression observed: high density CD8 with no CD4 expression; high density CD4 with low CD8 expression; or high density CD4 with higher cell surface CD8 expression which was regulated by the presence of rIL-4. CD4+ T cell clones originally cultured in IL-2 and rIL-4 and subsequently grown in IL-2 alone exhibited decreased expression of the CD8 molecule. The increased expression of CD8 did not correlate with NK activity or lectin-dependent cytotoxicity in an antigen independent system. In addition, rIL-4 alone or in combination with IL-2 appeared to accelerate the growth curve of T cell clones as compared to IL-2 alone. These results show that IL-4 can upregulate CD8 expression on CD4+ T cell clones while not effecting CD4 expression on CD8+ T cell clones. As class I MHC is the ligand for the CD8 molecule, expression of CD8 induced by IL-4 on CD4+ T cells may allow for increased nonspecific cell to cell contact during the course of an inflammatory response. | lld:pubmed |
| pubmed-article:2105169 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2105169 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2105169 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2105169 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2105169 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2105169 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2105169 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2105169 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2105169 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2105169 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2105169 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2105169 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:2105169 | pubmed:issn | 0008-8749 | lld:pubmed |
| pubmed-article:2105169 | pubmed:author | pubmed-author:BenjaminDD | lld:pubmed |
| pubmed-article:2105169 | pubmed:author | pubmed-author:HaflerD ADA | lld:pubmed |
| pubmed-article:2105169 | pubmed:author | pubmed-author:BrodS ASA | lld:pubmed |
| pubmed-article:2105169 | pubmed:author | pubmed-author:PurvesSS | lld:pubmed |
| pubmed-article:2105169 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2105169 | pubmed:volume | 125 | lld:pubmed |
| pubmed-article:2105169 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2105169 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2105169 | pubmed:pagination | 426-36 | lld:pubmed |
| pubmed-article:2105169 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:2105169 | pubmed:meshHeading | pubmed-meshheading:2105169-... | lld:pubmed |
| pubmed-article:2105169 | pubmed:meshHeading | pubmed-meshheading:2105169-... | lld:pubmed |
| pubmed-article:2105169 | pubmed:meshHeading | pubmed-meshheading:2105169-... | lld:pubmed |
| pubmed-article:2105169 | pubmed:meshHeading | pubmed-meshheading:2105169-... | lld:pubmed |
| pubmed-article:2105169 | pubmed:meshHeading | pubmed-meshheading:2105169-... | lld:pubmed |
| pubmed-article:2105169 | pubmed:meshHeading | pubmed-meshheading:2105169-... | lld:pubmed |
| pubmed-article:2105169 | pubmed:meshHeading | pubmed-meshheading:2105169-... | lld:pubmed |
| pubmed-article:2105169 | pubmed:meshHeading | pubmed-meshheading:2105169-... | lld:pubmed |
| pubmed-article:2105169 | pubmed:meshHeading | pubmed-meshheading:2105169-... | lld:pubmed |
| pubmed-article:2105169 | pubmed:meshHeading | pubmed-meshheading:2105169-... | lld:pubmed |
| pubmed-article:2105169 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2105169 | pubmed:articleTitle | Frequency analysis of CD4+CD8+ T cells cloned with IL-4. | lld:pubmed |
| pubmed-article:2105169 | pubmed:affiliation | Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115. | lld:pubmed |
| pubmed-article:2105169 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2105169 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2105169 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2105169 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2105169 | lld:pubmed |
