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pubmed-article:21048039pubmed:abstractTextThe phase III EXTREME study demonstrated that combining cetuximab with platinum/5-fluorouracil (5-FU) significantly improved overall survival in the first-line treatment of patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN) compared with platinum/5-FU alone. The aim of this investigation was to evaluate elevated tumor EGFR gene copy number as a predictive biomarker in EXTREME study patients.lld:pubmed
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pubmed-article:21048039pubmed:articleTitleEvaluation of EGFR gene copy number as a predictive biomarker for the efficacy of cetuximab in combination with chemotherapy in the first-line treatment of recurrent and/or metastatic squamous cell carcinoma of the head and neck: EXTREME study.lld:pubmed
pubmed-article:21048039pubmed:affiliationDivision of Medical Oncology, Istituto Nazionale Tumori, Milan, Italy.lld:pubmed
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pubmed-article:21048039pubmed:publicationTypeRandomized Controlled Triallld:pubmed
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