| pubmed-article:21041655 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21041655 | lifeskim:mentions | umls-concept:C0052441 | lld:lifeskim |
| pubmed-article:21041655 | lifeskim:mentions | umls-concept:C0011306 | lld:lifeskim |
| pubmed-article:21041655 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:21041655 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:21041655 | pubmed:issue | 46 | lld:pubmed |
| pubmed-article:21041655 | pubmed:dateCreated | 2010-11-18 | lld:pubmed |
| pubmed-article:21041655 | pubmed:abstractText | Although an immunoregulatory role of aryl hydrocarbon receptor (Ahr) has been demonstrated in T cells and macrophages, little is known about its function in dendritic cells (DC). Here, we show that lipopolysaccharide (LPS) and CpG stimulate Ahr expression in bone marrow-derived dendritic cells (BMDC). Furthermore, we found that Ahr is required to induce indoleamine 2,3-dioxygenase (IDO) expression, an immunosuppressive enzyme that catabolizes tryptophan into kynurenine (Kyn) and other metabolites in DC. In the presence of LPS or CpG, Ahr-deficient (Ahr(-/-)) mature BMDC induced immune responses characterized by reduced Kyn and IL-10 production compared with results observed with tolerogenic mature WT BMDC. In a coculture system with LPS- or CpG-stimulated BMDC and naive T cells, Ahr(-/-) BMDC inhibited naive T-cell differentiation into regulatory T (Treg) cells, which likely facilitated Th17 cell development and promoted naive T-cell proliferation. Addition of synthetic L-Kyn to the coculture system skewed the differentiation of naive T cells to Treg cells rather than Th17 cells. Taken together, our results demonstrate a previously unknown negatively regulatory role for Ahr in DC-mediated immunogenesis in the presence of LPS or CpG, which, in turn, alters the Kyn-dependent generation of Treg cells and Th17 cells from naive T cells. | lld:pubmed |
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| pubmed-article:21041655 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21041655 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21041655 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21041655 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:21041655 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21041655 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:21041655 | pubmed:issn | 1091-6490 | lld:pubmed |
| pubmed-article:21041655 | pubmed:author | pubmed-author:KishimotoTada... | lld:pubmed |
| pubmed-article:21041655 | pubmed:author | pubmed-author:NoharaKeikoK | lld:pubmed |
| pubmed-article:21041655 | pubmed:author | pubmed-author:Fujii-Kuriyam... | lld:pubmed |
| pubmed-article:21041655 | pubmed:author | pubmed-author:KimuraAkihiro... | lld:pubmed |
| pubmed-article:21041655 | pubmed:author | pubmed-author:NguyenNam... | lld:pubmed |
| pubmed-article:21041655 | pubmed:author | pubmed-author:NakahamaTaisu... | lld:pubmed |
| pubmed-article:21041655 | pubmed:author | pubmed-author:ChinenIchinoI | lld:pubmed |
| pubmed-article:21041655 | pubmed:author | pubmed-author:MasudaKazuyaK | lld:pubmed |
| pubmed-article:21041655 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21041655 | pubmed:day | 16 | lld:pubmed |
| pubmed-article:21041655 | pubmed:volume | 107 | lld:pubmed |
| pubmed-article:21041655 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21041655 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21041655 | pubmed:pagination | 19961-6 | lld:pubmed |
| pubmed-article:21041655 | pubmed:dateRevised | 2011-7-28 | lld:pubmed |
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| pubmed-article:21041655 | pubmed:year | 2010 | lld:pubmed |
