| pubmed-article:21038464 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21038464 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:21038464 | lifeskim:mentions | umls-concept:C0220905 | lld:lifeskim |
| pubmed-article:21038464 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:21038464 | pubmed:dateCreated | 2010-11-1 | lld:pubmed |
| pubmed-article:21038464 | pubmed:abstractText | B cells are now acknowledged to play multiple roles in the immune response, in addition to making antibodies. Their role in regulating T-cell responses during inflammation has come into focus recently. Thus, IL-10 production by B cells has been shown to be important in limiting auto-reactive and pathogen-driven immune pathology; however, the exact identity of the regulatory B cells remains elusive; do they belong to a committed subset or can all B cells regulate given the appropriate inducing stimuli? A study in this issue of the European Journal of Immunology provides insight into the IL-10-producing B cells in humans, suggesting that many B cells have the capacity to make IL-10 when optimally stimulated via the BCR and TLR9. Despite producing significant amounts of inflammatory cytokines as well, these B cells suppress T-cell proliferation. This Commentary places this study in the context of what we think we know about regulatory B cells and more importantly highlights the questions we still need to answer. | lld:pubmed |
| pubmed-article:21038464 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21038464 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21038464 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21038464 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21038464 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21038464 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21038464 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21038464 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21038464 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21038464 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:21038464 | pubmed:issn | 1521-4141 | lld:pubmed |
| pubmed-article:21038464 | pubmed:author | pubmed-author:GrayDavidD | lld:pubmed |
| pubmed-article:21038464 | pubmed:author | pubmed-author:GrayMohiniM | lld:pubmed |
| pubmed-article:21038464 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21038464 | pubmed:volume | 40 | lld:pubmed |
| pubmed-article:21038464 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21038464 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21038464 | pubmed:pagination | 2677-9 | lld:pubmed |
| pubmed-article:21038464 | pubmed:meshHeading | pubmed-meshheading:21038464... | lld:pubmed |
| pubmed-article:21038464 | pubmed:meshHeading | pubmed-meshheading:21038464... | lld:pubmed |
| pubmed-article:21038464 | pubmed:meshHeading | pubmed-meshheading:21038464... | lld:pubmed |
| pubmed-article:21038464 | pubmed:meshHeading | pubmed-meshheading:21038464... | lld:pubmed |
| pubmed-article:21038464 | pubmed:meshHeading | pubmed-meshheading:21038464... | lld:pubmed |
| pubmed-article:21038464 | pubmed:meshHeading | pubmed-meshheading:21038464... | lld:pubmed |
| pubmed-article:21038464 | pubmed:meshHeading | pubmed-meshheading:21038464... | lld:pubmed |
| pubmed-article:21038464 | pubmed:meshHeading | pubmed-meshheading:21038464... | lld:pubmed |
| pubmed-article:21038464 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:21038464 | pubmed:articleTitle | What are regulatory B cells? | lld:pubmed |
| pubmed-article:21038464 | pubmed:affiliation | Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Ashworth Labs, Edinburgh, UK. d.gray@ed.ac.uk | lld:pubmed |
| pubmed-article:21038464 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21038464 | pubmed:publicationType | Comment | lld:pubmed |
| pubmed-article:21038464 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:21038464 | lld:pubmed |
