| pubmed-article:21037199 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21037199 | lifeskim:mentions | umls-concept:C0031809 | lld:lifeskim |
| pubmed-article:21037199 | lifeskim:mentions | umls-concept:C0031842 | lld:lifeskim |
| pubmed-article:21037199 | lifeskim:mentions | umls-concept:C0030664 | lld:lifeskim |
| pubmed-article:21037199 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:21037199 | lifeskim:mentions | umls-concept:C0025921 | lld:lifeskim |
| pubmed-article:21037199 | lifeskim:mentions | umls-concept:C1511362 | lld:lifeskim |
| pubmed-article:21037199 | lifeskim:mentions | umls-concept:C2698297 | lld:lifeskim |
| pubmed-article:21037199 | lifeskim:mentions | umls-concept:C0018787 | lld:lifeskim |
| pubmed-article:21037199 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:21037199 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:21037199 | pubmed:dateCreated | 2010-11-1 | lld:pubmed |
| pubmed-article:21037199 | pubmed:abstractText | Human cardiomyopathies often lead to heart failure, a major cause of morbidity and mortality in industrialized nations. Described here is a phenotypic characterization of cardiac function and genome-wide expression from C3H/HeJ, C57BL/6J, and B6C3F1/J male mice. Histopathologic analysis identified a low-grade background cardiomyopathy (murine progressive cardiomyopathy) in eight of nine male C3H/HeJ mice (age nine to ten weeks), but not in male C57BL/6J and in only of ten male B6C3F1/J mice. The C3H/HeJ mouse had an increased heart rate and a shorter RR interval compared to the B6C3F1/J and C57BL/6J mice. Cardiac genomic studies indicated the B6C3F1/J mice exhibited an intermediate gene expression phenotype relative to the 2 parental strains. Disease-centric enrichment analysis indicated a number of cardiomyopathy-associated genes were induced in B6C3F1/J and C3H/HeJ mice, including Myh7, My14, and Lmna and also indicated differential expression of genes associated with metabolic (e.g., Pdk2) and hypoxic stress (e.g. Hif1a). A novel coexpression and integrated pathway network analysis indicated Prkaa2, Pdk2, Rhoj, and Sgcb are likely to play a central role in the pathophysiology of murine progressive cardiomyopathy in C3H/HeJ mice. Our studies indicate that genetically determined baseline differences in cardiac phenotype have the potential to influence the results of cardiotoxicity studies. | lld:pubmed |
| pubmed-article:21037199 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21037199 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21037199 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21037199 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21037199 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21037199 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21037199 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21037199 | pubmed:issn | 1533-1601 | lld:pubmed |
| pubmed-article:21037199 | pubmed:author | pubmed-author:XuHongH | lld:pubmed |
| pubmed-article:21037199 | pubmed:author | pubmed-author:NyskaAbrahamA | lld:pubmed |
| pubmed-article:21037199 | pubmed:author | pubmed-author:DunnickJune... | lld:pubmed |
| pubmed-article:21037199 | pubmed:author | pubmed-author:AuerbachScott... | lld:pubmed |
| pubmed-article:21037199 | pubmed:author | pubmed-author:ThomasReubenR | lld:pubmed |
| pubmed-article:21037199 | pubmed:author | pubmed-author:VallantMolly... | lld:pubmed |
| pubmed-article:21037199 | pubmed:author | pubmed-author:ShahRuchirR | lld:pubmed |
| pubmed-article:21037199 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21037199 | pubmed:volume | 38 | lld:pubmed |
| pubmed-article:21037199 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21037199 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21037199 | pubmed:pagination | 923-42 | lld:pubmed |
| pubmed-article:21037199 | pubmed:meshHeading | pubmed-meshheading:21037199... | lld:pubmed |
| pubmed-article:21037199 | pubmed:meshHeading | pubmed-meshheading:21037199... | lld:pubmed |
| pubmed-article:21037199 | pubmed:meshHeading | pubmed-meshheading:21037199... | lld:pubmed |
| pubmed-article:21037199 | pubmed:meshHeading | pubmed-meshheading:21037199... | lld:pubmed |
| pubmed-article:21037199 | pubmed:meshHeading | pubmed-meshheading:21037199... | lld:pubmed |
| pubmed-article:21037199 | pubmed:meshHeading | pubmed-meshheading:21037199... | lld:pubmed |
| pubmed-article:21037199 | pubmed:meshHeading | pubmed-meshheading:21037199... | lld:pubmed |
| pubmed-article:21037199 | pubmed:meshHeading | pubmed-meshheading:21037199... | lld:pubmed |
| pubmed-article:21037199 | pubmed:meshHeading | pubmed-meshheading:21037199... | lld:pubmed |
| pubmed-article:21037199 | pubmed:meshHeading | pubmed-meshheading:21037199... | lld:pubmed |
| pubmed-article:21037199 | pubmed:meshHeading | pubmed-meshheading:21037199... | lld:pubmed |
| pubmed-article:21037199 | pubmed:meshHeading | pubmed-meshheading:21037199... | lld:pubmed |
| pubmed-article:21037199 | pubmed:meshHeading | pubmed-meshheading:21037199... | lld:pubmed |
| pubmed-article:21037199 | pubmed:meshHeading | pubmed-meshheading:21037199... | lld:pubmed |
| pubmed-article:21037199 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:21037199 | pubmed:articleTitle | Comparative phenotypic assessment of cardiac pathology, physiology, and gene expression in C3H/HeJ, C57BL/6J, and B6C3F1/J mice. | lld:pubmed |
| pubmed-article:21037199 | pubmed:affiliation | National Toxicology Program, Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. | lld:pubmed |
| pubmed-article:21037199 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21037199 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:21037199 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| pubmed-article:21037199 | pubmed:publicationType | Research Support, N.I.H., Intramural | lld:pubmed |
