| pubmed-article:2100198 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2100198 | lifeskim:mentions | umls-concept:C0021747 | lld:lifeskim |
| pubmed-article:2100198 | lifeskim:mentions | umls-concept:C1314792 | lld:lifeskim |
| pubmed-article:2100198 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:2100198 | lifeskim:mentions | umls-concept:C0017263 | lld:lifeskim |
| pubmed-article:2100198 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:2100198 | lifeskim:mentions | umls-concept:C0443172 | lld:lifeskim |
| pubmed-article:2100198 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2100198 | pubmed:dateCreated | 1991-8-22 | lld:pubmed |
| pubmed-article:2100198 | pubmed:abstractText | Growth factors stimulate quiescent fibroblasts to progress through G0/G1, in part by inducing the expression of genes whose products are necessary or permissive for cell proliferation. Interferons, by contrast, inhibit progress through G0/G1 by mechanisms that are poorly understood. We show, in BALB/c murine 3T3 fibroblasts (A31 cells), that alpha/beta-interferon (IFN) had no effect the growth factor-dependent induction of several messenger ribonucleic acids (mRNAs), including those encoding ornithine decarboxylase (odc), fibronectin and the c-fos and c-myc protooncogenes. However, IFN caused an abnormal accumulation of fibronectin and c-myc mRNA on polysomes and markedly increased the stability of c-myc mRNA. Moreover, despite high, induced levels of mRNA, IFN inhibited the serum-stimulated rise in odc enzyme activity and the increased rate of fibronectin protein synthesis. By contrast, IFN had no effect on c-fos protein synthesis, nor did it affect the synthesis of most, but not all, proteins detectable by two-dimensional gel electrophoresis. The data suggest IFN inhibits proliferation by suppressing the expression of a subset of growth factor-inducible genes through a selective, posttranscriptional mechanism. | lld:pubmed |
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| pubmed-article:2100198 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2100198 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2100198 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2100198 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2100198 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2100198 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2100198 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2100198 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2100198 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2100198 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2100198 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2100198 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2100198 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2100198 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2100198 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:2100198 | pubmed:issn | 1044-2030 | lld:pubmed |
| pubmed-article:2100198 | pubmed:author | pubmed-author:LevineR ARA | lld:pubmed |
| pubmed-article:2100198 | pubmed:author | pubmed-author:CampisiJJ | lld:pubmed |
| pubmed-article:2100198 | pubmed:author | pubmed-author:HannS RSR | lld:pubmed |
| pubmed-article:2100198 | pubmed:author | pubmed-author:SeshadriTT | lld:pubmed |
| pubmed-article:2100198 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2100198 | pubmed:volume | 1 | lld:pubmed |
| pubmed-article:2100198 | pubmed:geneSymbol | c-fos | lld:pubmed |
| pubmed-article:2100198 | pubmed:geneSymbol | c-myc | lld:pubmed |
| pubmed-article:2100198 | pubmed:geneSymbol | odc | lld:pubmed |
| pubmed-article:2100198 | pubmed:geneSymbol | c-Ha-ras | lld:pubmed |
| pubmed-article:2100198 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2100198 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2100198 | pubmed:pagination | 215-26 | lld:pubmed |
| pubmed-article:2100198 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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