| pubmed-article:20979057 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20979057 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:20979057 | lifeskim:mentions | umls-concept:C0023884 | lld:lifeskim |
| pubmed-article:20979057 | lifeskim:mentions | umls-concept:C0694888 | lld:lifeskim |
| pubmed-article:20979057 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:20979057 | lifeskim:mentions | umls-concept:C1521840 | lld:lifeskim |
| pubmed-article:20979057 | lifeskim:mentions | umls-concept:C0065254 | lld:lifeskim |
| pubmed-article:20979057 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:20979057 | pubmed:dateCreated | 2011-1-21 | lld:pubmed |
| pubmed-article:20979057 | pubmed:abstractText | Liver tumor-initiating cells (T-ICs) are capable of self-renewal and tumor initiation and are more chemoresistant to chemotherapeutic drugs. The current therapeutic strategies for targeting stem cell self-renewal pathways therefore represent rational approaches for cancer prevention and treatment. In the present study, we found that Lup-20(29)-en-3?-ol (lupeol), a triterpene found in fruits and vegetables, inhibited the self-renewal ability of liver T-ICs present in both hepatocellular carcinoma (HCC) cell lines and clinical HCC samples, as reflected by hepatosphere formation. Furthermore, lupeol inhibited in vivo tumorigenicity in nude mice and down-regulated CD133 expression, which was previously shown to be a T-IC marker for HCC. In addition, lupeol sensitized HCC cells to chemotherapeutic agents through the phosphatase and tensin homolog (PTEN)-Akt-ABCG2 pathway. PTEN plays a crucial role in the self-renewal and chemoresistance of liver T-ICs; down-regulation of PTEN by a lentiviral-based approach reversed the effect of lupeol on liver T-ICs. Using an in vivo chemoresistant HCC tumor model, lupeol dramatically decreased the tumor volumes of MHCC-LM3 HCC cell line-derived xenografts, and the effect was equivalent to that of combined cisplatin and doxorubicin treatment. Lupeol exerted a synergistic effect without any adverse effects on body weight when combined with chemotherapeutic drugs. CONCLUSION: Our results suggest that lupeol may be an effective dietary phytochemical that targets liver T-ICs. | lld:pubmed |
| pubmed-article:20979057 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20979057 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20979057 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20979057 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20979057 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20979057 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20979057 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20979057 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20979057 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20979057 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20979057 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20979057 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20979057 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:20979057 | pubmed:issn | 1527-3350 | lld:pubmed |
| pubmed-article:20979057 | pubmed:author | pubmed-author:MaStephanieS | lld:pubmed |
| pubmed-article:20979057 | pubmed:author | pubmed-author:TangKwan HoKH | lld:pubmed |
| pubmed-article:20979057 | pubmed:author | pubmed-author:LeeTerence... | lld:pubmed |
| pubmed-article:20979057 | pubmed:author | pubmed-author:CastilhoAnton... | lld:pubmed |
| pubmed-article:20979057 | pubmed:author | pubmed-author:NgIrene Oi... | lld:pubmed |
| pubmed-article:20979057 | pubmed:author | pubmed-author:CheungVincent... | lld:pubmed |
| pubmed-article:20979057 | pubmed:copyrightInfo | Copyright © 2010 American Association for the Study of Liver Diseases. | lld:pubmed |
| pubmed-article:20979057 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20979057 | pubmed:volume | 53 | lld:pubmed |
| pubmed-article:20979057 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20979057 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20979057 | pubmed:pagination | 160-70 | lld:pubmed |
| pubmed-article:20979057 | pubmed:meshHeading | pubmed-meshheading:20979057... | lld:pubmed |
| pubmed-article:20979057 | pubmed:meshHeading | pubmed-meshheading:20979057... | lld:pubmed |
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| pubmed-article:20979057 | pubmed:meshHeading | pubmed-meshheading:20979057... | lld:pubmed |
| pubmed-article:20979057 | pubmed:meshHeading | pubmed-meshheading:20979057... | lld:pubmed |
| pubmed-article:20979057 | pubmed:meshHeading | pubmed-meshheading:20979057... | lld:pubmed |
| pubmed-article:20979057 | pubmed:meshHeading | pubmed-meshheading:20979057... | lld:pubmed |
| pubmed-article:20979057 | pubmed:meshHeading | pubmed-meshheading:20979057... | lld:pubmed |
| pubmed-article:20979057 | pubmed:meshHeading | pubmed-meshheading:20979057... | lld:pubmed |
| pubmed-article:20979057 | pubmed:meshHeading | pubmed-meshheading:20979057... | lld:pubmed |
| pubmed-article:20979057 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:20979057 | pubmed:articleTitle | Lupeol targets liver tumor-initiating cells through phosphatase and tensin homolog modulation. | lld:pubmed |
| pubmed-article:20979057 | pubmed:affiliation | State Key Laboratory for Liver Research, The University of Hong Kong, Hong Kong. | lld:pubmed |
| pubmed-article:20979057 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20979057 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
