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pubmed-article:20977777pubmed:abstractTextRecent observations indicate potential role of transcription factor STAT3 in cervical cancer development but its role specifically with respect to HPV infection is not known. Present study has been designed to investigate expression and activation of STAT3 in cervical precancer and cancer in relation to HPV infection during cervical carcinogenesis. Established cervical cancer cell lines and prospectively-collected cervical precancer and cancer tissues were analyzed for the HPV positivity and evaluated for STAT3 expression and its phosphorylation by immunoblotting and immunohistochemistry whereas STAT3-specific DNA binding activity was examined by gel-shift assays.lld:pubmed
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pubmed-article:20977777pubmed:articleTitleAberrant expression and constitutive activation of STAT3 in cervical carcinogenesis: implications in high-risk human papillomavirus infection.lld:pubmed
pubmed-article:20977777pubmed:affiliationDivision of Molecular Oncology, Institute of Cytology & Preventive Oncology, I-7, Sector-39, NOIDA, U.P., India.lld:pubmed
pubmed-article:20977777pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:20977777pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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