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pubmed-article:20975998pubmed:abstractTextInitial specification of cardiomyocytes in the mouse results from interactions between the extraembryonic anterior visceral endoderm (AVE) and the nascent mesoderm. However the mechanism by which AVE activates cardiogenesis is not well understood, and the identity of specific cardiogenic factors in the endoderm remains elusive. Most mammalian studies of the cardiogenic potential of the endoderm have relied on the use of cell lines that are similar to the heart-inducing AVE. These include the embryonal-carcinoma-derived cell lines, END2 and PYS2. The recent development of protocols to isolate eXtraembryonic ENdoderm (XEN) stem cells, representing the extraembryonic endoderm lineage, from blastocyst stage mouse embryos offers new tools for the genetic dissection of cardiogenesis.lld:pubmed
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pubmed-article:20975998pubmed:year2010lld:pubmed
pubmed-article:20975998pubmed:articleTitleeXtraembryonic ENdoderm (XEN) stem cells produce factors that activate heart formation.lld:pubmed
pubmed-article:20975998pubmed:affiliationGreenberg Division of Cardiology, Weill Cornell Medical College, New York, New York, United States of America.lld:pubmed
pubmed-article:20975998pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:20975998pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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