| pubmed-article:20975320 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20975320 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:20975320 | lifeskim:mentions | umls-concept:C1704242 | lld:lifeskim |
| pubmed-article:20975320 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:20975320 | lifeskim:mentions | umls-concept:C0019588 | lld:lifeskim |
| pubmed-article:20975320 | lifeskim:mentions | umls-concept:C0911014 | lld:lifeskim |
| pubmed-article:20975320 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:20975320 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:20975320 | lifeskim:mentions | umls-concept:C1883709 | lld:lifeskim |
| pubmed-article:20975320 | pubmed:issue | 5-6 | lld:pubmed |
| pubmed-article:20975320 | pubmed:dateCreated | 2010-12-23 | lld:pubmed |
| pubmed-article:20975320 | pubmed:abstractText | In the present study, the effects of ghrelin against the gastric damage induced by intragastric administration of 0.6 N HCl and the involvement of histamine H? receptors (H?Rs) were investigated in conscious rats with selective H?R ligands. Intraperitoneal (i.p.) injection of ghrelin (40 ?g/kg) significantly reduced (43%) the gastric lesions caused by concentrated acid. The effect of ghrelin was prevented by prior administration of the ghrelin receptor antagonist [D-Lys³]-GHRP-6 (100 ?g/kg i.p.) and by subcutaneous (s.c.) injection of the nonimidazole H?R antagonist UCL2138 (30 mg/kg). The selective H?R agonist immethridine (30 mg/kg s.c.) significantly inhibited (64.60%) the gastric lesions induced by 0.6 N HCl. The effect of immethridine was prevented by prior administration of UCL2138 (30 mg/kg s.c.), but not by [D-Lys³]-GHRP-6 (100 ?g/kg i.p.). Neither [D-Lys³]-GHRP-6 nor UCL2138 modified HCl-induced gastric damage per se. These data enlarge previous studies showing protective effects of ghrelin against ulcerogenic stimuli; in addition, they clearly indicate that ghrelin-induced gastroprotection involves the release of histamine, which enhances gastric mucosal defense through the activation of histamine H?Rs. | lld:pubmed |
| pubmed-article:20975320 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20975320 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20975320 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20975320 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20975320 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20975320 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20975320 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20975320 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20975320 | pubmed:issn | 1423-0313 | lld:pubmed |
| pubmed-article:20975320 | pubmed:author | pubmed-author:LeursRobR | lld:pubmed |
| pubmed-article:20975320 | pubmed:author | pubmed-author:StarkHolgerH | lld:pubmed |
| pubmed-article:20975320 | pubmed:author | pubmed-author:AdamiMaristel... | lld:pubmed |
| pubmed-article:20975320 | pubmed:author | pubmed-author:CoruzziGabrie... | lld:pubmed |
| pubmed-article:20975320 | pubmed:author | pubmed-author:PozzoliCristi... | lld:pubmed |
| pubmed-article:20975320 | pubmed:copyrightInfo | Copyright © 2010 S. Karger AG, Basel. | lld:pubmed |
| pubmed-article:20975320 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20975320 | pubmed:volume | 86 | lld:pubmed |
| pubmed-article:20975320 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20975320 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20975320 | pubmed:pagination | 259-66 | lld:pubmed |
| pubmed-article:20975320 | pubmed:meshHeading | pubmed-meshheading:20975320... | lld:pubmed |
| pubmed-article:20975320 | pubmed:meshHeading | pubmed-meshheading:20975320... | lld:pubmed |
| pubmed-article:20975320 | pubmed:meshHeading | pubmed-meshheading:20975320... | lld:pubmed |
| pubmed-article:20975320 | pubmed:meshHeading | pubmed-meshheading:20975320... | lld:pubmed |
| pubmed-article:20975320 | pubmed:meshHeading | pubmed-meshheading:20975320... | lld:pubmed |
| pubmed-article:20975320 | pubmed:meshHeading | pubmed-meshheading:20975320... | lld:pubmed |
| pubmed-article:20975320 | pubmed:meshHeading | pubmed-meshheading:20975320... | lld:pubmed |
| pubmed-article:20975320 | pubmed:meshHeading | pubmed-meshheading:20975320... | lld:pubmed |
| pubmed-article:20975320 | pubmed:meshHeading | pubmed-meshheading:20975320... | lld:pubmed |
| pubmed-article:20975320 | pubmed:meshHeading | pubmed-meshheading:20975320... | lld:pubmed |
| pubmed-article:20975320 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20975320 | pubmed:articleTitle | Histamine H(3) receptors are involved in the protective effect of ghrelin against HCl-induced gastric damage in rats. | lld:pubmed |
| pubmed-article:20975320 | pubmed:affiliation | Department of Human Anatomy, Pharmacology and Forensic Medicine, Section of Pharmacology, University of Parma, Parma, Italy. | lld:pubmed |
| pubmed-article:20975320 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20975320 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:59301 | entrezgene:pubmed | pubmed-article:20975320 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:20975320 | lld:entrezgene |
