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pubmed-article:20974185pubmed:dateCreated2010-12-20lld:pubmed
pubmed-article:20974185pubmed:abstractTextPrevious results demonstrated association between increased FosB/?FosB immunostaining in the ventromedial striatum and behavioral sensitization to amphetamine promoted by repeated stress or by repeated pairings of the psychostimulant and the testing cage in mice of the C57BL/6J strain. The present experiments tested this association in an additional protocol, its stability following the end of the sensitizing procedure and its generalization to mice from a different inbred strain. Eleven days after repeated administration of amphetamine within their home-cages, mice of the C57BL/6J strain expressed sensitization to the psychomotor effects of the psychostimulant when tested in a novel cage. At this time-point the same mice showed increased FosB/?FosB immunostaining in the ventromedial striatum. Instead, mice of the genetically unrelated DBA/2J inbred strain expressing robust sensitization in the same protocol did not show changes in FosB/?FosB immunostaining throughout the striatal complex. Lack of effects in FosB/?FosB immunostaining was also observed in DBA/2J mice behaviorally sensitized by repeated pairings of amphetamine with the test cage. These results demonstrate that mice, depending on the genetic background, can develop robust and long-lasting behavioral sensitization to amphetamine in the absence of striatal ?FosB accumulation.lld:pubmed
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pubmed-article:20974185pubmed:authorpubmed-author:ColelliVVlld:pubmed
pubmed-article:20974185pubmed:copyrightInfoCopyright © 2010 Elsevier B.V. All rights reserved.lld:pubmed
pubmed-article:20974185pubmed:issnTypeElectroniclld:pubmed
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pubmed-article:20974185pubmed:volume217lld:pubmed
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pubmed-article:20974185pubmed:articleTitleAssociation between striatal accumulation of FosB/?FosB and long-term psychomotor sensitization to amphetamine in mice depends on the genetic background.lld:pubmed
pubmed-article:20974185pubmed:affiliationDepartment of Psychology, Center D. Bovet, University Sapienza, Rome, Italy.lld:pubmed
pubmed-article:20974185pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:20974185pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:20974185pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed