| pubmed-article:20972438 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20972438 | lifeskim:mentions | umls-concept:C0012655 | lld:lifeskim |
| pubmed-article:20972438 | lifeskim:mentions | umls-concept:C0005684 | lld:lifeskim |
| pubmed-article:20972438 | lifeskim:mentions | umls-concept:C2350277 | lld:lifeskim |
| pubmed-article:20972438 | lifeskim:mentions | umls-concept:C1708726 | lld:lifeskim |
| pubmed-article:20972438 | lifeskim:mentions | umls-concept:C0439064 | lld:lifeskim |
| pubmed-article:20972438 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:20972438 | pubmed:dateCreated | 2010-10-28 | lld:pubmed |
| pubmed-article:20972438 | pubmed:abstractText | We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies followed by a replication strategy, which included 8,382 cases and 48,275 controls from 16 studies. In a combined analysis, we identified three new regions associated with bladder cancer on chromosomes 22q13.1, 19q12 and 2q37.1: rs1014971, (P = 8 × 10?¹²) maps to a non-genic region of chromosome 22q13.1, rs8102137 (P = 2 × 10?¹¹) on 19q12 maps to CCNE1 and rs11892031 (P = 1 × 10??) maps to the UGT1A cluster on 2q37.1. We confirmed four previously identified genome-wide associations on chromosomes 3q28, 4p16.3, 8q24.21 and 8q24.3, validated previous candidate associations for the GSTM1 deletion (P = 4 × 10?¹¹) and a tag SNP for NAT2 acetylation status (P = 4 × 10?¹¹), and found interactions with smoking in both regions. Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis. | lld:pubmed |
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| pubmed-article:20972438 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20972438 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20972438 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:20972438 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20972438 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:20972438 | pubmed:issn | 1546-1718 | lld:pubmed |
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