Linked Life Data

20965236

Source:http://linkedlifedata.com/resource/pubmed/id/20965236

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SubjectPredicateObjectContext
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pubmed-article:20965236pubmed:dateCreated2011-1-10lld:pubmed
pubmed-article:20965236pubmed:abstractTextIn cattle, bovine leukocyte antigens (BoLAs) have been extensively used as markers for bovine diseases and immunological traits. In this study, we sequenced alleles of the BoLA class II loci, BoLA-DRB3 and BoLA-DQA1, from 650 Japanese cattle from six herds [three herds (507 animals) of Japanese Black cattle and three herds (143 animals) of Holstein cattle] using polymerase chain reaction-sequence-based typing (PCR-SBT) methods. We identified 26 previously reported distinct DRB3 alleles in the two populations: 22 in Japanese Black and 17 in Holstein. The number of DRB3 alleles detected in each herd ranged from 9 to 20. Next, we identified 15 previously reported distinct DQA1 alleles: 13 in Japanese Black and 10 in Holstein. The number of alleles in each herd ranged from 6 to 10. Thus, allelic divergence is significantly greater for DRB3 than for DQA1. A population tree on the basis of the frequencies of the DRB3 and DQA1 alleles showed that, although the genetic distance differed significantly between the two cattle breeds, it was closely related within the three herds of each breed. In addition, Wu-Kabat variability analysis indicated that the DRB3 gene was more polymorphic than the DQA1 gene in both breeds and in all herds, and that the majority of the hypervariable positions within both loci corresponded to pocket-forming residues. The DRB3 and DQA1 heterozygosity for both breeds within each herd were calculated based on the Hardy-Weinberg equilibrium. Only one Japanese Black herd showed a significant difference between the expected and observed heterozygosity at both loci. This is the first report presenting a detailed study of the allelic distribution of BoLA-DRB3 and -DQA1 genes in Japanese Black and Holstein cattle from different farms in Japan. These results may help to develop improved livestock breeding strategies in the future.lld:pubmed
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pubmed-article:20965236pubmed:authorpubmed-author:AidaYokoYlld:pubmed
pubmed-article:20965236pubmed:authorpubmed-author:KobayashiNaoh...lld:pubmed
pubmed-article:20965236pubmed:authorpubmed-author:TanabeYoshihi...lld:pubmed
pubmed-article:20965236pubmed:authorpubmed-author:SentsuiHirosh...lld:pubmed
pubmed-article:20965236pubmed:authorpubmed-author:MatsumotoYuki...lld:pubmed
pubmed-article:20965236pubmed:authorpubmed-author:MiyazakiYoshi...lld:pubmed
pubmed-article:20965236pubmed:authorpubmed-author:MatsuhashiTam...lld:pubmed
pubmed-article:20965236pubmed:authorpubmed-author:TakeshimaShin...lld:pubmed
pubmed-article:20965236pubmed:authorpubmed-author:IshibashiKazu...lld:pubmed
pubmed-article:20965236pubmed:authorpubmed-author:MiyasakaTakuTlld:pubmed
pubmed-article:20965236pubmed:copyrightInfoCopyright © 2010 Elsevier B.V. All rights reserved.lld:pubmed
pubmed-article:20965236pubmed:issnTypeElectroniclld:pubmed
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pubmed-article:20965236pubmed:volume472lld:pubmed
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pubmed-article:20965236pubmed:pagination42-9lld:pubmed
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pubmed-article:20965236pubmed:year2011lld:pubmed
pubmed-article:20965236pubmed:articleTitleThe diversity of bovine MHC class II DRB3 and DQA1 alleles in different herds of Japanese Black and Holstein cattle in Japan.lld:pubmed
pubmed-article:20965236pubmed:affiliationViral Infectious Diseases Unit, RIKEN, Wako, Saitama, Japan.lld:pubmed
pubmed-article:20965236pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:20965236pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed