| pubmed-article:20961755 | pubmed:abstractText | Five new highly brominated metabolites, 3',5',6',6-tetrabromo-2,4-dimethyldiphenyl ether (1), 1,2,5-tribromo-3-bromoamino-7-bromomethylnaphthalene (2), 2,5,8-tribromo-3-bromoamino-7-bromomethylnaphthalene (3), 2,5,6-tribromo-3-bromoamino-7-bromomethylnaphthalene (4) and 2',5',6',5,6-pentabromo-3',4',3,4-tetramethoxybenzo-phenone (5) were isolated from the red alga Laurencia similis. Their structures were elucidated by spectroscopic methods including one- and two- dimensional NMR as well as HREIMS analysis. Compounds 1 and 5 showed strong inhibitory activities against protein tyrosine phosphatase 1B (PTP1B) with IC(50) of 2.97 and 2.66 ?M, respectively. | lld:pubmed |
