| pubmed-article:20960282 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20960282 | lifeskim:mentions | umls-concept:C0206419 | lld:lifeskim |
| pubmed-article:20960282 | lifeskim:mentions | umls-concept:C0008139 | lld:lifeskim |
| pubmed-article:20960282 | lifeskim:mentions | umls-concept:C0017968 | lld:lifeskim |
| pubmed-article:20960282 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:20960282 | pubmed:dateCreated | 2010-10-20 | lld:pubmed |
| pubmed-article:20960282 | pubmed:abstractText | A group of SARS-like coronaviruses (SL-CoV) have been identified in horseshoe bats. Despite SL-CoVs and SARS-CoV share identical genome structure and high-level sequence similarity, SL-CoV does not bind to the same cellular receptor as for SARS-CoV and the N-terminus of the S proteins only share 64% amino acid identity, suggesting there are fundamental differences between these two groups of coronaviruses. To gain insight into the basis of this difference, we established a recombinant adenovirus system expressing the S protein from SL-CoV (rAd-Rp3-S) to investigate its immune characterization. Our results showed that immunized mice generated strong humoral immune responses against the SL-CoV S protein. Moreover, a strong cellular immune response demonstrated by elevated IFN-? and IL-6 levels was also observed in these mice. However, the induced antibody from these mice had weaker cross-reaction with the SARS-CoV S protein, and did not neutralize HIV pseudotyped with SARS-CoV S protein. These results demonstrated that the immunogenicity of the SL-CoV S protein is distinct from that of SARS-CoV, which may cause the immunological differences between human SARS-CoV and bat SL-CoV. Furthermore, the recombinant virus could serve as a potential vaccine candidate against bat SL-CoV infection. | lld:pubmed |
| pubmed-article:20960282 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20960282 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20960282 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20960282 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20960282 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20960282 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20960282 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20960282 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20960282 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20960282 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20960282 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20960282 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20960282 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20960282 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:20960282 | pubmed:issn | 1995-820X | lld:pubmed |
| pubmed-article:20960282 | pubmed:author | pubmed-author:ZhouPengP | lld:pubmed |
| pubmed-article:20960282 | pubmed:author | pubmed-author:ChengPengP | lld:pubmed |
| pubmed-article:20960282 | pubmed:author | pubmed-author:HouYu-xuanYX | lld:pubmed |
| pubmed-article:20960282 | pubmed:author | pubmed-author:HanZheng-gang... | lld:pubmed |
| pubmed-article:20960282 | pubmed:author | pubmed-author:ChenJi-guoJG | lld:pubmed |
| pubmed-article:20960282 | pubmed:author | pubmed-author:ShiZheng-liZL | lld:pubmed |
| pubmed-article:20960282 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20960282 | pubmed:volume | 25 | lld:pubmed |
| pubmed-article:20960282 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20960282 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20960282 | pubmed:pagination | 36-44 | lld:pubmed |
| pubmed-article:20960282 | pubmed:meshHeading | pubmed-meshheading:20960282... | lld:pubmed |
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| pubmed-article:20960282 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20960282 | pubmed:articleTitle | Immunogenicity of the spike glycoprotein of bat SARS-like coronavirus. | lld:pubmed |
| pubmed-article:20960282 | pubmed:affiliation | State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China. | lld:pubmed |
| pubmed-article:20960282 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20960282 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
