| pubmed-article:20951034 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20951034 | lifeskim:mentions | umls-concept:C0020205 | lld:lifeskim |
| pubmed-article:20951034 | lifeskim:mentions | umls-concept:C0003374 | lld:lifeskim |
| pubmed-article:20951034 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:20951034 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:20951034 | lifeskim:mentions | umls-concept:C0048060 | lld:lifeskim |
| pubmed-article:20951034 | pubmed:issue | 23 | lld:pubmed |
| pubmed-article:20951034 | pubmed:dateCreated | 2010-11-8 | lld:pubmed |
| pubmed-article:20951034 | pubmed:abstractText | Despite emergence of resistance to CQ and other 4-aminoquinoline drugs in most of the endemic regions, research findings provide considerable support that there is still significant potential to discover new affordable, safe, and efficacious 4-aminoquinoline antimalarials. In present study, new side chain modified 4-aminoquinoline derivatives and quinoline-acridine hybrids were synthesized and evaluated in vitro against NF 54 strain of Plasmodium falciparum. Among the evaluated compounds, compound 17 (MIC=0.125 ?g/mL) was equipotent to standard drug CQ (MIC=0.125 ?g/mL) and compound 21 (MIC=0.031 ?g/mL) was four times more potent than CQ. Compound 17 showed the curative response to all the treated swiss mice infected with CQ-resistant N-67 strain of Plasmodium yoelii at the doses 50 mg/kg and 25 mg/kg for four days by intraperitoneal route and was found to be orally active at the dose of 100 mg/kg for four days. The promising antimalarial potency of compound 17 highlights the significance of exploring the privileged 4-aminoquinoline class for new antimalarials. | lld:pubmed |
| pubmed-article:20951034 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20951034 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20951034 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20951034 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20951034 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20951034 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20951034 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20951034 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20951034 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20951034 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:20951034 | pubmed:issn | 1464-3405 | lld:pubmed |
| pubmed-article:20951034 | pubmed:author | pubmed-author:RybaDD | lld:pubmed |
| pubmed-article:20951034 | pubmed:author | pubmed-author:KumarAshokA | lld:pubmed |
| pubmed-article:20951034 | pubmed:author | pubmed-author:ChauhanPrem... | lld:pubmed |
| pubmed-article:20951034 | pubmed:author | pubmed-author:SrivastavaKum... | lld:pubmed |
| pubmed-article:20951034 | pubmed:author | pubmed-author:KumarS RajaSR | lld:pubmed |
| pubmed-article:20951034 | pubmed:copyrightInfo | Copyright © 2010. Published by Elsevier Ltd. | lld:pubmed |
| pubmed-article:20951034 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20951034 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:20951034 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:20951034 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20951034 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20951034 | pubmed:pagination | 7059-63 | lld:pubmed |
| pubmed-article:20951034 | pubmed:meshHeading | pubmed-meshheading:20951034... | lld:pubmed |
| pubmed-article:20951034 | pubmed:meshHeading | pubmed-meshheading:20951034... | lld:pubmed |
| pubmed-article:20951034 | pubmed:meshHeading | pubmed-meshheading:20951034... | lld:pubmed |
| pubmed-article:20951034 | pubmed:meshHeading | pubmed-meshheading:20951034... | lld:pubmed |
| pubmed-article:20951034 | pubmed:meshHeading | pubmed-meshheading:20951034... | lld:pubmed |
| pubmed-article:20951034 | pubmed:meshHeading | pubmed-meshheading:20951034... | lld:pubmed |
| pubmed-article:20951034 | pubmed:meshHeading | pubmed-meshheading:20951034... | lld:pubmed |
| pubmed-article:20951034 | pubmed:meshHeading | pubmed-meshheading:20951034... | lld:pubmed |
| pubmed-article:20951034 | pubmed:meshHeading | pubmed-meshheading:20951034... | lld:pubmed |
| pubmed-article:20951034 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20951034 | pubmed:articleTitle | Synthesis of new 4-aminoquinolines and quinoline-acridine hybrids as antimalarial agents. | lld:pubmed |
| pubmed-article:20951034 | pubmed:affiliation | Division of Medicinal & Process Chemistry, Central Drug Research Institute, Lucknow, India. | lld:pubmed |
| pubmed-article:20951034 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20951034 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:20951034 | lld:chembl |
