| pubmed-article:20948318 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20948318 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:20948318 | lifeskim:mentions | umls-concept:C1378703 | lld:lifeskim |
| pubmed-article:20948318 | lifeskim:mentions | umls-concept:C1518174 | lld:lifeskim |
| pubmed-article:20948318 | lifeskim:mentions | umls-concept:C1516119 | lld:lifeskim |
| pubmed-article:20948318 | lifeskim:mentions | umls-concept:C1366521 | lld:lifeskim |
| pubmed-article:20948318 | lifeskim:mentions | umls-concept:C1149234 | lld:lifeskim |
| pubmed-article:20948318 | lifeskim:mentions | umls-concept:C0086982 | lld:lifeskim |
| pubmed-article:20948318 | lifeskim:mentions | umls-concept:C0439064 | lld:lifeskim |
| pubmed-article:20948318 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:20948318 | lifeskim:mentions | umls-concept:C1524066 | lld:lifeskim |
| pubmed-article:20948318 | lifeskim:mentions | umls-concept:C1999177 | lld:lifeskim |
| pubmed-article:20948318 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:20948318 | pubmed:dateCreated | 2011-1-13 | lld:pubmed |
| pubmed-article:20948318 | pubmed:abstractText | We have determined whether an adenovirus that comprises the tail and shaft domains of a serotype 5 virus and the knob domain of a serotype 3 virus expressing MDA-7/IL-24, Ad.5/3-mda-7, more effectively infects and kills renal carcinoma cells (RCCs) compared to a serotype 5 virus, Ad.5-mda-7. RCCs are a tumor cell type that generally does not express the receptor for the type 5 adenovirus; the coxsackie and adenovirus receptor (CAR). Ad.5/3-mda-7 infected RCCs to a much greater degree than Ad.5-mda-7. MDA-7/IL-24 protein secreted from Ad.5/3-mda-7-infected RCCs induced MDA-7/IL-24 expression and promoted apoptosis in uninfected "bystander" RCCs. MDA-7/IL-24 killed both infected and bystander RCCs via CD95 activation. Knockdown of intracellular MDA-7/IL-24 in uninfected RCCs blocked the lethal effects of conditioned media. Infection of RCC tumors in one flank, with Ad.5/3-mda-7, suppressed growth of infected tumors and reduced the growth rate of uninfected tumors implanted on the opposite flank. The toxicity of the serotype 5/3 recombinant adenovirus to express MDA-7/IL-24 was enhanced by combined molecular or small molecule inhibition of MEK1/2 and PI3K; inhibition of mTOR, PI3K and MEK1/2; or use of the multi-kinase inhibitor sorafenib. In RCCs, combined inhibition of cytoprotective cell signaling pathways enhanced the MDA-7/IL-24-induction of CD95 activation, with greater mitochondrial dysfunction due to loss of MCL-1 and BCL-XL expression, and tumor cell death. Treatment of RCC tumors in vivo with sorafenib also enhanced Ad.5/3-mda-7 toxicity and prolonged animal survival. Future combinations of these approaches hold promise for developing a more effective therapy for kidney cancer. | lld:pubmed |
| pubmed-article:20948318 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20948318 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20948318 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20948318 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20948318 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:20948318 | pubmed:issn | 1555-8576 | lld:pubmed |
| pubmed-article:20948318 | pubmed:author | pubmed-author:DentPaulP | lld:pubmed |
| pubmed-article:20948318 | pubmed:author | pubmed-author:CurielDavid... | lld:pubmed |
| pubmed-article:20948318 | pubmed:author | pubmed-author:FisherPaul... | lld:pubmed |
| pubmed-article:20948318 | pubmed:author | pubmed-author:DmitrievIgor... | lld:pubmed |
| pubmed-article:20948318 | pubmed:author | pubmed-author:ChenYangY | lld:pubmed |
| pubmed-article:20948318 | pubmed:author | pubmed-author:YacoubAdlyA | lld:pubmed |
| pubmed-article:20948318 | pubmed:author | pubmed-author:HamedHosseinH | lld:pubmed |
| pubmed-article:20948318 | pubmed:author | pubmed-author:ParkMargaret... | lld:pubmed |
| pubmed-article:20948318 | pubmed:author | pubmed-author:EulittPatrick... | lld:pubmed |
| pubmed-article:20948318 | pubmed:author | pubmed-author:CruikshanksNi... | lld:pubmed |
| pubmed-article:20948318 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20948318 | pubmed:day | 12 | lld:pubmed |
| pubmed-article:20948318 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:20948318 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20948318 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20948318 | pubmed:pagination | 1290-305 | lld:pubmed |
| pubmed-article:20948318 | pubmed:dateRevised | 2011-7-28 | lld:pubmed |
