| pubmed-article:20943987 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20943987 | lifeskim:mentions | umls-concept:C0042760 | lld:lifeskim |
| pubmed-article:20943987 | lifeskim:mentions | umls-concept:C0206679 | lld:lifeskim |
| pubmed-article:20943987 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:20943987 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:20943987 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:20943987 | lifeskim:mentions | umls-concept:C0005528 | lld:lifeskim |
| pubmed-article:20943987 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:20943987 | lifeskim:mentions | umls-concept:C1522492 | lld:lifeskim |
| pubmed-article:20943987 | lifeskim:mentions | umls-concept:C0205225 | lld:lifeskim |
| pubmed-article:20943987 | pubmed:issue | 24 | lld:pubmed |
| pubmed-article:20943987 | pubmed:dateCreated | 2010-11-24 | lld:pubmed |
| pubmed-article:20943987 | pubmed:abstractText | After primary replication at the site of entry into the host, alphaherpesviruses infect and establish latency in neurons. To this end, they are transported within axons retrograde from the periphery to the cell body for replication and in an anterograde direction to synapses for infection of higher-order neurons or back to the periphery. Retrograde transport of incoming nucleocapsids is well documented. In contrast, there is still significant controversy on the mode of anterograde transport. By high-resolution transmission electron microscopy of primary neuronal cultures from embryonic rat superior cervical ganglia infected by pseudorabies virus (PrV), we observed the presence of enveloped virions in axons within vesicles supporting the "married model" of anterograde transport of complete virus particles within vesicles (C. Maresch, H. Granzow, A. Negatsch, B.G. Klupp, W. Fuchs, J.P. Teifke, and T.C. Mettenleiter, J. Virol. 84:5528-5539, 2010). We have now extended these analyses to the related human herpes simplex virus type 1 (HSV-1). We have demonstrated that in neurons infected by HSV-1 strains HFEM, 17+ or SC16, approximately 75% of virus particles observed intraaxonally or in growth cones late after infection constitute enveloped virions within vesicles, whereas approximately 25% present as naked capsids. In general, the number of HSV-1 particles in the axons was significantly less than that observed after PrV infection. | lld:pubmed |
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| pubmed-article:20943987 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20943987 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20943987 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20943987 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20943987 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:20943987 | pubmed:issn | 1098-5514 | lld:pubmed |
| pubmed-article:20943987 | pubmed:author | pubmed-author:FuchsWalterW | lld:pubmed |
| pubmed-article:20943987 | pubmed:author | pubmed-author:KluppBarbara... | lld:pubmed |
| pubmed-article:20943987 | pubmed:author | pubmed-author:GranzowHarald... | lld:pubmed |
| pubmed-article:20943987 | pubmed:author | pubmed-author:MettenleiterT... | lld:pubmed |
| pubmed-article:20943987 | pubmed:author | pubmed-author:TeifkeJens... | lld:pubmed |
| pubmed-article:20943987 | pubmed:author | pubmed-author:MareschChrist... | lld:pubmed |
| pubmed-article:20943987 | pubmed:author | pubmed-author:NegatschAlexa... | lld:pubmed |
| pubmed-article:20943987 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20943987 | pubmed:volume | 84 | lld:pubmed |
| pubmed-article:20943987 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20943987 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20943987 | pubmed:pagination | 13031-5 | lld:pubmed |
| pubmed-article:20943987 | pubmed:dateRevised | 2011-7-28 | lld:pubmed |
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| pubmed-article:20943987 | pubmed:meshHeading | pubmed-meshheading:20943987... | lld:pubmed |
| pubmed-article:20943987 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20943987 | pubmed:articleTitle | Ultrastructural analysis of virion formation and intraaxonal transport of herpes simplex virus type 1 in primary rat neurons. | lld:pubmed |
| pubmed-article:20943987 | pubmed:affiliation | Friedrich-Loeffler-Institut, Südufer 10, 17493 Greifswald-Insel Riems, Germany. | lld:pubmed |
| pubmed-article:20943987 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20943987 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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