| pubmed-article:20933060 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20933060 | lifeskim:mentions | umls-concept:C0006684 | lld:lifeskim |
| pubmed-article:20933060 | lifeskim:mentions | umls-concept:C0815000 | lld:lifeskim |
| pubmed-article:20933060 | lifeskim:mentions | umls-concept:C0178719 | lld:lifeskim |
| pubmed-article:20933060 | lifeskim:mentions | umls-concept:C0201925 | lld:lifeskim |
| pubmed-article:20933060 | lifeskim:mentions | umls-concept:C0006685 | lld:lifeskim |
| pubmed-article:20933060 | lifeskim:mentions | umls-concept:C0288263 | lld:lifeskim |
| pubmed-article:20933060 | lifeskim:mentions | umls-concept:C1099354 | lld:lifeskim |
| pubmed-article:20933060 | lifeskim:mentions | umls-concept:C0220908 | lld:lifeskim |
| pubmed-article:20933060 | lifeskim:mentions | umls-concept:C1413495 | lld:lifeskim |
| pubmed-article:20933060 | lifeskim:mentions | umls-concept:C1707391 | lld:lifeskim |
| pubmed-article:20933060 | lifeskim:mentions | umls-concept:C1709060 | lld:lifeskim |
| pubmed-article:20933060 | lifeskim:mentions | umls-concept:C0547047 | lld:lifeskim |
| pubmed-article:20933060 | lifeskim:mentions | umls-concept:C0750502 | lld:lifeskim |
| pubmed-article:20933060 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:20933060 | pubmed:dateCreated | 2010-12-27 | lld:pubmed |
| pubmed-article:20933060 | pubmed:abstractText | Defects of the CLN3 gene on chromosome 16p12.1 lead to the juvenile form of neuronal ceroid-lipofuscinosis (JNCL, Batten Disease), the most common recessive inherited neurodegenerative disorder in children. Dysregulation of intracellular calcium homeostasis in the absence of a functional CLN3 protein (CLN3P, Battenin) has been linked to synaptic dysfunction and accelerated apoptosis in vulnerable neuronal cells. Prolonged increase of intracellular calcium concentration is considered to be a significant trigger for neuronal apoptosis and cellular loss in JNCL. | lld:pubmed |
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| pubmed-article:20933060 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:20933060 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:20933060 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20933060 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:20933060 | pubmed:issn | 0006-3002 | lld:pubmed |
| pubmed-article:20933060 | pubmed:author | pubmed-author:HoV YVY | lld:pubmed |
| pubmed-article:20933060 | pubmed:author | pubmed-author:BennettMichae... | lld:pubmed |
| pubmed-article:20933060 | pubmed:author | pubmed-author:NarayanSriniv... | lld:pubmed |
| pubmed-article:20933060 | pubmed:author | pubmed-author:WarnockAshley... | lld:pubmed |
| pubmed-article:20933060 | pubmed:author | pubmed-author:An... | lld:pubmed |
| pubmed-article:20933060 | pubmed:author | pubmed-author:LiHayingH | lld:pubmed |
| pubmed-article:20933060 | pubmed:copyrightInfo | Copyright © 2010 Elsevier B.V. All rights reserved. | lld:pubmed |
| pubmed-article:20933060 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:20933060 | pubmed:volume | 1810 | lld:pubmed |
| pubmed-article:20933060 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20933060 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20933060 | pubmed:pagination | 186-91 | lld:pubmed |
| pubmed-article:20933060 | pubmed:dateRevised | 2011-7-28 | lld:pubmed |
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| pubmed-article:20933060 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:20933060 | pubmed:articleTitle | Screening for calcium channel modulators in CLN3 siRNA knock down SH-SY5Y neuroblastoma cells reveals a significant decrease of intracellular calcium levels by selected L-type calcium channel blockers. | lld:pubmed |
| pubmed-article:20933060 | pubmed:affiliation | Department of Pathology and Laboratory Medicine, Division of Metabolic Disease, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA. anhaackk@email.chop.edu | lld:pubmed |
