| pubmed-article:20926579 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20926579 | lifeskim:mentions | umls-concept:C0033414 | lld:lifeskim |
| pubmed-article:20926579 | lifeskim:mentions | umls-concept:C1326631 | lld:lifeskim |
| pubmed-article:20926579 | lifeskim:mentions | umls-concept:C0021665 | lld:lifeskim |
| pubmed-article:20926579 | lifeskim:mentions | umls-concept:C0175630 | lld:lifeskim |
| pubmed-article:20926579 | lifeskim:mentions | umls-concept:C0205250 | lld:lifeskim |
| pubmed-article:20926579 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
| pubmed-article:20926579 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:20926579 | pubmed:dateCreated | 2010-11-24 | lld:pubmed |
| pubmed-article:20926579 | pubmed:abstractText | Animal studies have shown that IGF-I is essential for mammary gland development. Previous studies have suggested that local IGF-I rather than circulating IGF-I is the major mediator of mammary gland development. In the present study we used the hepatic IGF-I transgenic (HIT) and IGF-I knockout/HIT (KO-HIT) mouse models to examine the effects of enhanced circulating IGF-I on mammary development in the presence and absence of local IGF-I. HIT mice express the rat IGF-I transgene under the transthyretin promoter in the liver and have elevated circulating IGF-I and normal tissue IGF-I levels. The KO-HIT mice have no tissue IGF-I and increased circulating IGF-I. Analysis of mammary gland development reveals a greater degree of complexity in HIT mice as compared to control and KO-HIT mice, which demonstrate similar degrees of mammary gland complexity. Immunohistochemical evaluation of glands of HIT mice also suggests an enhanced degree of proliferation of the mammary gland, whereas KO-HIT mice exhibit mammary gland proliferation similar to control mice. In addition, HIT mice have a higher percentage of proliferating myoepithelial and luminal cells than control mice, whereas KO-HIT mice have an equivalent percentage of proliferating myoepithelial and luminal cells as control mice. Thus, our findings show that elevated circulating IGF-I levels are sufficient to promote normal pubertal mammary epithelial development. However, HIT mice demonstrate more pronounced mammary gland development when compared to control and KO-HIT mice. This suggests that both local and endocrine IGF-I play roles in mammary gland development and that elevated circulating IGF-I accelerates mammary epithelial proliferation. | lld:pubmed |
| pubmed-article:20926579 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20926579 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20926579 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20926579 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20926579 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20926579 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:20926579 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20926579 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20926579 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20926579 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:20926579 | pubmed:issn | 1945-7170 | lld:pubmed |
| pubmed-article:20926579 | pubmed:author | pubmed-author:SunHuiH | lld:pubmed |
| pubmed-article:20926579 | pubmed:author | pubmed-author:YakarShoshana... | lld:pubmed |
| pubmed-article:20926579 | pubmed:author | pubmed-author:WoodTeresa... | lld:pubmed |
| pubmed-article:20926579 | pubmed:author | pubmed-author:LeroithDerekD | lld:pubmed |
| pubmed-article:20926579 | pubmed:author | pubmed-author:WuYingjieY | lld:pubmed |
| pubmed-article:20926579 | pubmed:author | pubmed-author:LazzarinoDebo... | lld:pubmed |
| pubmed-article:20926579 | pubmed:author | pubmed-author:LannDanielleD | lld:pubmed |
| pubmed-article:20926579 | pubmed:author | pubmed-author:ElisSebastien... | lld:pubmed |
| pubmed-article:20926579 | pubmed:author | pubmed-author:CannataDaraD | lld:pubmed |
| pubmed-article:20926579 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20926579 | pubmed:volume | 151 | lld:pubmed |
| pubmed-article:20926579 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20926579 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20926579 | pubmed:pagination | 5751-61 | lld:pubmed |
| pubmed-article:20926579 | pubmed:meshHeading | pubmed-meshheading:20926579... | lld:pubmed |
| pubmed-article:20926579 | pubmed:meshHeading | pubmed-meshheading:20926579... | lld:pubmed |
| pubmed-article:20926579 | pubmed:meshHeading | pubmed-meshheading:20926579... | lld:pubmed |
| pubmed-article:20926579 | pubmed:meshHeading | pubmed-meshheading:20926579... | lld:pubmed |
| pubmed-article:20926579 | pubmed:meshHeading | pubmed-meshheading:20926579... | lld:pubmed |
| pubmed-article:20926579 | pubmed:meshHeading | pubmed-meshheading:20926579... | lld:pubmed |
| pubmed-article:20926579 | pubmed:meshHeading | pubmed-meshheading:20926579... | lld:pubmed |
| pubmed-article:20926579 | pubmed:meshHeading | pubmed-meshheading:20926579... | lld:pubmed |
| pubmed-article:20926579 | pubmed:meshHeading | pubmed-meshheading:20926579... | lld:pubmed |
| pubmed-article:20926579 | pubmed:meshHeading | pubmed-meshheading:20926579... | lld:pubmed |
| pubmed-article:20926579 | pubmed:meshHeading | pubmed-meshheading:20926579... | lld:pubmed |
| pubmed-article:20926579 | pubmed:meshHeading | pubmed-meshheading:20926579... | lld:pubmed |
| pubmed-article:20926579 | pubmed:meshHeading | pubmed-meshheading:20926579... | lld:pubmed |
| pubmed-article:20926579 | pubmed:meshHeading | pubmed-meshheading:20926579... | lld:pubmed |
| pubmed-article:20926579 | pubmed:meshHeading | pubmed-meshheading:20926579... | lld:pubmed |
| pubmed-article:20926579 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20926579 | pubmed:articleTitle | Elevated circulating IGF-I promotes mammary gland development and proliferation. | lld:pubmed |
| pubmed-article:20926579 | pubmed:affiliation | Division of Endocrinology, Diabetes, and Bone Diseases, The Samuel Bronfman Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA. | lld:pubmed |
| pubmed-article:20926579 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20926579 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:16000 | entrezgene:pubmed | pubmed-article:20926579 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:20926579 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:20926579 | lld:pubmed |
