| pubmed-article:20926112 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20926112 | lifeskim:mentions | umls-concept:C0029347 | lld:lifeskim |
| pubmed-article:20926112 | lifeskim:mentions | umls-concept:C1615053 | lld:lifeskim |
| pubmed-article:20926112 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:20926112 | lifeskim:mentions | umls-concept:C2076600 | lld:lifeskim |
| pubmed-article:20926112 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:20926112 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:20926112 | lifeskim:mentions | umls-concept:C1524062 | lld:lifeskim |
| pubmed-article:20926112 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:20926112 | lifeskim:mentions | umls-concept:C0596072 | lld:lifeskim |
| pubmed-article:20926112 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:20926112 | pubmed:dateCreated | 2010-10-25 | lld:pubmed |
| pubmed-article:20926112 | pubmed:abstractText | Spiro[piperidine-2,2'-adamantane] 4 is one of the most potent synthetic anti-influenza A aminoadamantanes or other cage structure amines tested so far. Based on previous results Tataridis et al. (2007) [5h] which demonstrate the boost of in vitro potency by the presence of an additional amino group, we examined whether the incorporation of a second amino group into this heterocycle would increase the anti-influenza A virus activity. The new synthetic molecules 5-7 are capable of forming two hydrogen bonds within the receptor. We identified the diamino derivatives 5 and 6, which are active against influenza A H3N2 virus although less potent than amantadine and its equipotent spiropiperidine 4. | lld:pubmed |
| pubmed-article:20926112 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20926112 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20926112 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20926112 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20926112 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20926112 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20926112 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20926112 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20926112 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20926112 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20926112 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:20926112 | pubmed:issn | 1090-2120 | lld:pubmed |
| pubmed-article:20926112 | pubmed:author | pubmed-author:BaslerChristo... | lld:pubmed |
| pubmed-article:20926112 | pubmed:author | pubmed-author:KolocourisAnt... | lld:pubmed |
| pubmed-article:20926112 | pubmed:author | pubmed-author:FytasGeorgeG | lld:pubmed |
| pubmed-article:20926112 | pubmed:author | pubmed-author:ZoidisGrigori... | lld:pubmed |
| pubmed-article:20926112 | pubmed:author | pubmed-author:FytasChristos... | lld:pubmed |
| pubmed-article:20926112 | pubmed:author | pubmed-author:ValmasCharala... | lld:pubmed |
| pubmed-article:20926112 | pubmed:copyrightInfo | Copyright © 2010 Elsevier Inc. All rights reserved. | lld:pubmed |
| pubmed-article:20926112 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20926112 | pubmed:volume | 38 | lld:pubmed |
| pubmed-article:20926112 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20926112 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20926112 | pubmed:pagination | 247-51 | lld:pubmed |
| pubmed-article:20926112 | pubmed:meshHeading | pubmed-meshheading:20926112... | lld:pubmed |
| pubmed-article:20926112 | pubmed:meshHeading | pubmed-meshheading:20926112... | lld:pubmed |
| pubmed-article:20926112 | pubmed:meshHeading | pubmed-meshheading:20926112... | lld:pubmed |
| pubmed-article:20926112 | pubmed:meshHeading | pubmed-meshheading:20926112... | lld:pubmed |
| pubmed-article:20926112 | pubmed:meshHeading | pubmed-meshheading:20926112... | lld:pubmed |
| pubmed-article:20926112 | pubmed:meshHeading | pubmed-meshheading:20926112... | lld:pubmed |
| pubmed-article:20926112 | pubmed:meshHeading | pubmed-meshheading:20926112... | lld:pubmed |
| pubmed-article:20926112 | pubmed:meshHeading | pubmed-meshheading:20926112... | lld:pubmed |
| pubmed-article:20926112 | pubmed:meshHeading | pubmed-meshheading:20926112... | lld:pubmed |
| pubmed-article:20926112 | pubmed:meshHeading | pubmed-meshheading:20926112... | lld:pubmed |
| pubmed-article:20926112 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20926112 | pubmed:articleTitle | Influence of an additional amino group on the potency of aminoadamantanes against influenza virus A. II - Synthesis of spiropiperazines and in vitro activity against influenza A H3N2 virus. | lld:pubmed |
| pubmed-article:20926112 | pubmed:affiliation | Department of Pharmaceutical Chemistry, University of Athens, Greece. | lld:pubmed |
| pubmed-article:20926112 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20926112 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:20926112 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
